ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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PR domain zinc finger protein 9

Intramolecular
Cysteine 54 and cysteine 29
Cysteine 54 and cysteine 337
A redox-regulated disulphide may form within PR domain zinc finger protein 9 between cysteines 54 and 29 (721 and 724 respectively in this structure).

Details

Redox score ?
87
PDB code
5v3g
Structure name
prdm9-allele-c znf8-13
Structure deposition date
2017-03-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
36
Minimum pKa ?
6
% buried
0
Peptide accession
D9IWL3
Residue number A
54
Residue number B
29
Peptide name
PR domain zinc finger protein 9

Ligandability

Cysteine 54 of PR domain zinc finger protein 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 29 of PR domain zinc finger protein 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within PR domain zinc finger protein 9 between cysteines 54 and 337 (749 and 752 respectively in this structure).

Details

Redox score ?
82
PDB code
5v3g
Structure name
prdm9-allele-c znf8-13
Structure deposition date
2017-03-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
48
Minimum pKa ?
8
% buried
8
Peptide accession
D9IWL3
Residue number A
54
Residue number B
337
Peptide name
PR domain zinc finger protein 9

Ligandability

Cysteine 54 of PR domain zinc finger protein 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 337 of PR domain zinc finger protein 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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