ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Chloride channel protein

Intramolecular
Cysteine 297 and cysteine 515
Cysteine 297 and cysteine 302
A redox-regulated disulphide may form within Chloride channel protein between cysteines 297 and 515.

Details

Redox score ?
70
PDB code
5tr1
Structure name
cryo-electron microscopy structure of a bovine clc-k chloride channel, alternate (class 2) conformation
Structure deposition date
2016-10-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
9
% buried
26
Peptide accession
E1B792
Residue number A
297
Residue number B
515
Peptide name
Chloride channel protein

Ligandability

Cysteine 297 of Chloride channel protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 515 of Chloride channel protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Chloride channel protein between cysteines 297 and 302. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
5tqq
Structure name
cryo-electron microscopy structure of a bovine clc-k chloride channel, main (class 1) conformation
Structure deposition date
2016-10-24
Thiol separation (Å)
10
Half-sphere exposure sum ?
62
Minimum pKa ?
10
% buried
25
Peptide accession
E1B792
Residue number A
297
Residue number B
302
Peptide name
Chloride channel protein

Ligandability

Cysteine 297 of Chloride channel protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 302 of Chloride channel protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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