ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Bardet-Biedl syndrome 9

Intramolecular
Cysteine 783 and cysteine 826
Cysteine 136 and cysteine 153
A redox-regulated disulphide may form within Bardet-Biedl syndrome 9 between cysteines 783 and 826.

Details

Redox score ?
68
PDB code
6vbv
Structure name
structure of the bovine bbsome:arl6:gtp complex
Structure deposition date
2019-12-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
51
Minimum pKa ?
8
% buried
24
Peptide accession
E1BHJ5
Residue number A
783
Residue number B
826
Peptide name
Bardet-Biedl syndrome 9

Ligandability

Cysteine 783 of Bardet-Biedl syndrome 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 826 of Bardet-Biedl syndrome 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Bardet-Biedl syndrome 9 between cysteines 136 and 153. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
23
PDB code
6vbu
Structure name
structure of the bovine bbsome complex
Structure deposition date
2019-12-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
84
Minimum pKa ?
13
% buried
100
Peptide accession
E1BHJ5
Residue number A
136
Residue number B
153
Peptide name
Bardet-Biedl syndrome 9

Ligandability

Cysteine 136 of Bardet-Biedl syndrome 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 153 of Bardet-Biedl syndrome 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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