ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Tubulin beta chain

Intramolecular
Cysteine 239 and cysteine 354
Cysteine 127 and cysteine 129
A redox-regulated disulphide may form within Tubulin beta chain between cysteines 239 and 354 (241 and 356 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
6wvm
Structure name
high curvature lateral interaction within a 13-protofilament, taxol stabilized microtubule
Structure deposition date
2020-05-06
Thiol separation (Å)
6
Half-sphere exposure sum ?
77
Minimum pKa ?
11
% buried
100
Peptide accession
E1BJB1
Residue number A
239
Residue number B
354
Peptide name
Tubulin beta chain

Ligandability

Cysteine 239 of Tubulin beta chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 354 of Tubulin beta chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tubulin beta chain between cysteines 127 and 129 (129 and 131 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
6wvm
Structure name
high curvature lateral interaction within a 13-protofilament, taxol stabilized microtubule
Structure deposition date
2020-05-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
49
Minimum pKa ?
11
% buried
62
Peptide accession
E1BJB1
Residue number A
127
Residue number B
129
Peptide name
Tubulin beta chain

Ligandability

Cysteine 127 of Tubulin beta chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 129 of Tubulin beta chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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