ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Bardet-Biedl syndrome 1

Intramolecular
Cysteine 341 and cysteine 359
A redox-regulated disulphide may form within Bardet-Biedl syndrome 1 between cysteines 341 and 359 (267 and 285 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
6vbv
Structure name
structure of the bovine bbsome:arl6:gtp complex
Structure deposition date
2019-12-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
74
Minimum pKa ?
10
% buried
66
Peptide accession
E1BN34
Residue number A
341
Residue number B
359
Peptide name
Bardet-Biedl syndrome 1

Ligandability

Cysteine 341 of Bardet-Biedl syndrome 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 359 of Bardet-Biedl syndrome 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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