ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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UNC79

Intermolecular
Cysteine 541 and cysteine 2958 of Protein unc-80 homolog
Intramolecular
Cysteine 1407 and cysteine 2027
Cysteine 2027 and cysteine 2030
Cysteine 1407 and cysteine 2030
Cysteine 1341 and cysteine 1354
Cysteine 805 and cysteine 808
Cysteine 819 and cysteine 925
Cysteine 2484 and cysteine 2489
Cysteine 2261 and cysteine 2264
Cysteine 930 and cysteine 935
More...
Cysteine 512 and cysteine 570
Cysteine 1041 and cysteine 1042
Cysteine 1339 and cysteine 1341
Cysteine 2261 and cysteine 2339
Cysteine 814 and cysteine 925
Cysteine 1074 and cysteine 1076
Cysteine 1018 and cysteine 1076
Cysteine 1041 and cysteine 1076
Cysteine 1041 and cysteine 1074
A redox-regulated disulphide may form between cysteine 541 of UNC79 and cysteine 2958 of Protein unc-80 homolog. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
7w7g
Structure name
structure of mammalian nalcn-fam155a-unc79-unc80 quanternary complex
Structure deposition date
2021-12-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
39
Peptide A name
UNC79
Peptide B name
Protein unc-80 homolog
Peptide A accession
E5CYJ9
Peptide B accession
B8XCJ6
Peptide A residue number
541
Peptide B residue number
2958

Ligandability

Cysteine 541 of UNC79

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2958 of Protein unc-80 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within UNC79 between cysteines 1407 and 2027.

Details

Redox score ?
85
PDB code
7w7g
Structure name
structure of mammalian nalcn-fam155a-unc79-unc80 quanternary complex
Structure deposition date
2021-12-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
41
Minimum pKa ?
7
% buried
4
Peptide accession
E5CYJ9
Residue number A
1407
Residue number B
2027
Peptide name
UNC79

Ligandability

Cysteine 1407 of UNC79

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2027 of UNC79

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within UNC79 between cysteines 2027 and 2030.

Details

Redox score ?
84
PDB code
7w7g
Structure name
structure of mammalian nalcn-fam155a-unc79-unc80 quanternary complex
Structure deposition date
2021-12-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
39
Minimum pKa ?
7
% buried
4
Peptide accession
E5CYJ9
Residue number A
2027
Residue number B
2030
Peptide name
UNC79

Ligandability

Cysteine 2027 of UNC79

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2030 of UNC79

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within UNC79 between cysteines 1407 and 2030.

Details

Redox score ?
84
PDB code
7w7g
Structure name
structure of mammalian nalcn-fam155a-unc79-unc80 quanternary complex
Structure deposition date
2021-12-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
28
Minimum pKa ?
9
% buried
0
Peptide accession
E5CYJ9
Residue number A
1407
Residue number B
2030
Peptide name
UNC79

Ligandability

Cysteine 1407 of UNC79

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2030 of UNC79

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within UNC79 between cysteines 1341 and 1354.

Details

Redox score ?
74
PDB code
7w7g
Structure name
structure of mammalian nalcn-fam155a-unc79-unc80 quanternary complex
Structure deposition date
2021-12-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
7
% buried
71
Peptide accession
E5CYJ9
Residue number A
1341
Residue number B
1354
Peptide name
UNC79

Ligandability

Cysteine 1341 of UNC79

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1354 of UNC79

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within UNC79 between cysteines 805 and 808.

Details

Redox score ?
63
PDB code
7w7g
Structure name
structure of mammalian nalcn-fam155a-unc79-unc80 quanternary complex
Structure deposition date
2021-12-04
Thiol separation (Å)
7
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
10
Peptide accession
E5CYJ9
Residue number A
805
Residue number B
808
Peptide name
UNC79

Ligandability

Cysteine 805 of UNC79

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 808 of UNC79

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within UNC79 between cysteines 819 and 925.

Details

Redox score ?
62
PDB code
7w7g
Structure name
structure of mammalian nalcn-fam155a-unc79-unc80 quanternary complex
Structure deposition date
2021-12-04
Thiol separation (Å)
5
Half-sphere exposure sum ?
79
Minimum pKa ?
9
% buried
98
Peptide accession
E5CYJ9
Residue number A
819
Residue number B
925
Peptide name
UNC79

Ligandability

Cysteine 819 of UNC79

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 925 of UNC79

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within UNC79 between cysteines 2484 and 2489. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
7w7g
Structure name
structure of mammalian nalcn-fam155a-unc79-unc80 quanternary complex
Structure deposition date
2021-12-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
56
Minimum pKa ?
8
% buried
24
Peptide accession
E5CYJ9
Residue number A
2484
Residue number B
2489
Peptide name
UNC79

Ligandability

Cysteine 2484 of UNC79

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2489 of UNC79

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within UNC79 between cysteines 2261 and 2264. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
7w7g
Structure name
structure of mammalian nalcn-fam155a-unc79-unc80 quanternary complex
Structure deposition date
2021-12-04
Thiol separation (Å)
7
Half-sphere exposure sum ?
83
Minimum pKa ?
11
% buried
88
Peptide accession
E5CYJ9
Residue number A
2261
Residue number B
2264
Peptide name
UNC79

Ligandability

Cysteine 2261 of UNC79

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2264 of UNC79

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within UNC79 between cysteines 930 and 935. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
7w7g
Structure name
structure of mammalian nalcn-fam155a-unc79-unc80 quanternary complex
Structure deposition date
2021-12-04
Thiol separation (Å)
7
Half-sphere exposure sum ?
80
Minimum pKa ?
12
% buried
100
Peptide accession
E5CYJ9
Residue number A
930
Residue number B
935
Peptide name
UNC79

Ligandability

Cysteine 930 of UNC79

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 935 of UNC79

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within UNC79 between cysteines 512 and 570. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
7w7g
Structure name
structure of mammalian nalcn-fam155a-unc79-unc80 quanternary complex
Structure deposition date
2021-12-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
56
Minimum pKa ?
10
% buried
31
Peptide accession
E5CYJ9
Residue number A
512
Residue number B
570
Peptide name
UNC79

Ligandability

Cysteine 512 of UNC79

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 570 of UNC79

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within UNC79 between cysteines 1041 and 1042. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
7w7g
Structure name
structure of mammalian nalcn-fam155a-unc79-unc80 quanternary complex
Structure deposition date
2021-12-04
Thiol separation (Å)
7
Half-sphere exposure sum ?
88
Minimum pKa ?
12
% buried
100
Peptide accession
E5CYJ9
Residue number A
1041
Residue number B
1042
Peptide name
UNC79

Ligandability

Cysteine 1041 of UNC79

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1042 of UNC79

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within UNC79 between cysteines 1339 and 1341. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
7w7g
Structure name
structure of mammalian nalcn-fam155a-unc79-unc80 quanternary complex
Structure deposition date
2021-12-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
77
Minimum pKa ?
13
% buried
88
Peptide accession
E5CYJ9
Residue number A
1339
Residue number B
1341
Peptide name
UNC79

Ligandability

Cysteine 1339 of UNC79

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1341 of UNC79

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within UNC79 between cysteines 2261 and 2339. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
7w7g
Structure name
structure of mammalian nalcn-fam155a-unc79-unc80 quanternary complex
Structure deposition date
2021-12-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
69
Minimum pKa ?
11
% buried
80
Peptide accession
E5CYJ9
Residue number A
2261
Residue number B
2339
Peptide name
UNC79

Ligandability

Cysteine 2261 of UNC79

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2339 of UNC79

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within UNC79 between cysteines 814 and 925. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
7w7g
Structure name
structure of mammalian nalcn-fam155a-unc79-unc80 quanternary complex
Structure deposition date
2021-12-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
81
Minimum pKa ?
9
% buried
100
Peptide accession
E5CYJ9
Residue number A
814
Residue number B
925
Peptide name
UNC79

Ligandability

Cysteine 814 of UNC79

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 925 of UNC79

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within UNC79 between cysteines 1074 and 1076. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
7w7g
Structure name
structure of mammalian nalcn-fam155a-unc79-unc80 quanternary complex
Structure deposition date
2021-12-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
80
Minimum pKa ?
12
% buried
100
Peptide accession
E5CYJ9
Residue number A
1074
Residue number B
1076
Peptide name
UNC79

Ligandability

Cysteine 1074 of UNC79

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1076 of UNC79

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within UNC79 between cysteines 1018 and 1076. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
7w7g
Structure name
structure of mammalian nalcn-fam155a-unc79-unc80 quanternary complex
Structure deposition date
2021-12-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
83
Minimum pKa ?
12
% buried
100
Peptide accession
E5CYJ9
Residue number A
1018
Residue number B
1076
Peptide name
UNC79

Ligandability

Cysteine 1018 of UNC79

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1076 of UNC79

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within UNC79 between cysteines 1041 and 1076. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
26
PDB code
7w7g
Structure name
structure of mammalian nalcn-fam155a-unc79-unc80 quanternary complex
Structure deposition date
2021-12-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
86
Minimum pKa ?
12
% buried
100
Peptide accession
E5CYJ9
Residue number A
1041
Residue number B
1076
Peptide name
UNC79

Ligandability

Cysteine 1041 of UNC79

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1076 of UNC79

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within UNC79 between cysteines 1041 and 1074. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
22
PDB code
7w7g
Structure name
structure of mammalian nalcn-fam155a-unc79-unc80 quanternary complex
Structure deposition date
2021-12-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
87
Minimum pKa ?
13
% buried
100
Peptide accession
E5CYJ9
Residue number A
1041
Residue number B
1074
Peptide name
UNC79

Ligandability

Cysteine 1041 of UNC79

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1074 of UNC79

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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