Poly [ADP-ribose] polymerase

Intramolecular

A redox-regulated disulphide may form within Poly [ADP-ribose] polymerase between cysteines 997 and 1008 (1234 and 1245 respectively in this structure).

Details

Redox score ?

PDB code

7ocv

Structure name

human tnks1 in complex with 3-[4-(1-hydroxy-1-methyl-ethyl)-phenyl]-6- methyl-2h-pyrrolo[1,2-a]pyrazin-1-one

Structure deposition date

2021-04-28

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

E7EQ52

Residue number A

997

Residue number B

1008

Peptide name

Poly [ADP-ribose] polymerase

Ligandability

Cysteine 997 of Poly [ADP-ribose] polymerase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1008 of Poly [ADP-ribose] polymerase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Poly [ADP-ribose] polymerase between cysteines 997 and 1005 (1234 and 1242 respectively in this structure).

Details

Redox score ?

PDB code

7ocv

Structure name

human tnks1 in complex with 3-[4-(1-hydroxy-1-methyl-ethyl)-phenyl]-6- methyl-2h-pyrrolo[1,2-a]pyrazin-1-one

Structure deposition date

2021-04-28

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

E7EQ52

Residue number A

997

Residue number B

1005

Peptide name

Poly [ADP-ribose] polymerase

Ligandability

Cysteine 997 of Poly [ADP-ribose] polymerase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1005 of Poly [ADP-ribose] polymerase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Poly [ADP-ribose] polymerase between cysteines 1005 and 1008 (1242 and 1245 respectively in this structure).