ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Uncharacterized protein

Intermolecular
Cysteine 224 and cysteine 34 of C-C motif chemokine 3
Cysteine 235 and cysteine 34 of C-C motif chemokine 3
A redox-regulated disulphide may form between cysteine 224 of Uncharacterized protein and cysteine 34 of C-C motif chemokine 3 (197 and 11 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
4zlt
Structure name
crystal structure of viral chemokine binding protein r17 in complex with ccl3
Structure deposition date
2015-05-01
Thiol separation (Å)
10
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide A name
Uncharacterized protein
Peptide B name
C-C motif chemokine 3
Peptide A accession
E9M5R0
Peptide B accession
P10855
Peptide A residue number
224
Peptide B residue number
34

Ligandability

Cysteine 224 of Uncharacterized protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 34 of C-C motif chemokine 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 235 of Uncharacterized protein and cysteine 34 of C-C motif chemokine 3 (208 and 11 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
4zlt
Structure name
crystal structure of viral chemokine binding protein r17 in complex with ccl3
Structure deposition date
2015-05-01
Thiol separation (Å)
10
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide A name
Uncharacterized protein
Peptide B name
C-C motif chemokine 3
Peptide A accession
E9M5R0
Peptide B accession
P10855
Peptide A residue number
235
Peptide B residue number
34

Ligandability

Cysteine 235 of Uncharacterized protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 34 of C-C motif chemokine 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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