a tool for identifying drug-targetable redox-active disulphides

TEA domain transcription factor 1

Intramolecular

Cysteine 306 and cysteine 309

A redox-regulated disulphide may form within TEA domain transcription factor 1 between cysteines 306 and 309 (402 and 405 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

34

PDB code

Structure name

crystal structure analysis of human tead1

Structure deposition date

2021-01-26

Thiol separation (Å)

9

Half-sphere exposure sum ?

78

Minimum pK_a ?

13

% buried

100

Peptide accession

Residue number A

306

Residue number B

309

Peptide name

TEA domain transcription factor 1

Ligandability

Cysteine 306 of TEA domain transcription factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 309 of TEA domain transcription factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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