Dipeptidylpeptidase 6
Intermolecular
Cysteine 233 of Potassium voltage-gated channel subfamily D member 3 and cysteine 101
Intramolecular
Cysteine 521 and cysteine 524
Cysteine 405 and cysteine 412
Cysteine 729 and cysteine 840
Cysteine 530 and cysteine 548
Cysteine 524 and cysteine 530
Cysteine 521 and cysteine 530
7w6t B 233 I 46
A redox-regulated disulphide may form between cysteine 233 of Potassium voltage-gated channel subfamily D member 3 and cysteine 101 of Dipeptidylpeptidase 6 (233 and 46 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
7w6t
Structure name
cryoem structure of human kchip1-kv4
Structure deposition date
2021-12-02
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
46
Peptide A name
Potassium voltage-gated channel subfamily D member 3
Peptide B name
Dipeptidylpeptidase 6
Peptide A accession
Q9UK17
Peptide B accession
E9PWX1
Peptide A residue number
233
Peptide B residue number
101
Ligandability
Cysteine 233 of Potassium voltage-gated channel subfamily D member 3
Cysteine 101 of Dipeptidylpeptidase 6
7w6t J 466 J 469
A redox-regulated disulphide may form within Dipeptidylpeptidase 6 between cysteines 521 and 524 (466 and 469 respectively in this structure).
Details
Redox score ?
85
PDB code
7w6t
Structure name
cryoem structure of human kchip1-kv4
Structure deposition date
2021-12-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
E9PWX1
Residue number A
521
Residue number B
524
Peptide name
Dipeptidylpeptidase 6
Ligandability
Cysteine 521 of Dipeptidylpeptidase 6
Cysteine 524 of Dipeptidylpeptidase 6
7w6t I 350 I 357
A redox-regulated disulphide may form within Dipeptidylpeptidase 6 between cysteines 405 and 412 (350 and 357 respectively in this structure).
Details
Redox score ?
85
PDB code
7w6t
Structure name
cryoem structure of human kchip1-kv4
Structure deposition date
2021-12-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
E9PWX1
Residue number A
405
Residue number B
412
Peptide name
Dipeptidylpeptidase 6
Ligandability
Cysteine 405 of Dipeptidylpeptidase 6
Cysteine 412 of Dipeptidylpeptidase 6
7w6t J 674 J 785
A redox-regulated disulphide may form within Dipeptidylpeptidase 6 between cysteines 729 and 840 (674 and 785 respectively in this structure).
Details
Redox score ?
82
PDB code
7w6t
Structure name
cryoem structure of human kchip1-kv4
Structure deposition date
2021-12-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
E9PWX1
Residue number A
729
Residue number B
840
Peptide name
Dipeptidylpeptidase 6
Ligandability
Cysteine 729 of Dipeptidylpeptidase 6
Cysteine 840 of Dipeptidylpeptidase 6
7w6t J 475 J 493
A redox-regulated disulphide may form within Dipeptidylpeptidase 6 between cysteines 530 and 548 (475 and 493 respectively in this structure).
Details
Redox score ?
81
PDB code
7w6t
Structure name
cryoem structure of human kchip1-kv4
Structure deposition date
2021-12-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
E9PWX1
Residue number A
530
Residue number B
548
Peptide name
Dipeptidylpeptidase 6
Ligandability
Cysteine 530 of Dipeptidylpeptidase 6
Cysteine 548 of Dipeptidylpeptidase 6
7w6t I 469 I 475
A redox-regulated disulphide may form within Dipeptidylpeptidase 6 between cysteines 524 and 530 (469 and 475 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
7w6t
Structure name
cryoem structure of human kchip1-kv4
Structure deposition date
2021-12-02
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
E9PWX1
Residue number A
524
Residue number B
530
Peptide name
Dipeptidylpeptidase 6
Ligandability
Cysteine 524 of Dipeptidylpeptidase 6
Cysteine 530 of Dipeptidylpeptidase 6
7w6t I 466 I 475
A redox-regulated disulphide may form within Dipeptidylpeptidase 6 between cysteines 521 and 530 (466 and 475 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
7w6t
Structure name
cryoem structure of human kchip1-kv4
Structure deposition date
2021-12-02
Thiol separation (Å)
10
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
E9PWX1
Residue number A
521
Residue number B
530
Peptide name
Dipeptidylpeptidase 6
Ligandability
Cysteine 521 of Dipeptidylpeptidase 6
Cysteine 530 of Dipeptidylpeptidase 6
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