a tool for identifying drug-targetable redox-active disulphides

Pre-mRNA processing factor 39

Intramolecular

Cysteine 377 and cysteine 381

A redox-regulated disulphide may form within Pre-mRNA processing factor 39 between cysteines 377 and 381.

Details

Redox score ?

69

PDB code

Structure name

structure of murine prpf39

Structure deposition date

2018-04-04

Thiol separation (Å)

4

Half-sphere exposure sum ?

76

Minimum pK_a ?

9

% buried

94

Peptide accession

Residue number A

377

Residue number B

381

Peptide name

Pre-mRNA processing factor 39

Ligandability

Cysteine 377 of Pre-mRNA processing factor 39

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 381 of Pre-mRNA processing factor 39

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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