ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Fuzzy planar cell polarity protein

Intermolecular
Cysteine 838 of Protein inturned and cysteine 365
Intramolecular
Cysteine 151 and cysteine 309
Cysteine 154 and cysteine 309
Cysteine 151 and cysteine 154
Cysteine 247 and cysteine 250
A redox-regulated disulphide may form between cysteine 838 of Protein inturned and cysteine 365 of Fuzzy planar cell polarity protein. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
7q3e
Structure name
structure of the mouse cplane-rsg1 complex
Structure deposition date
2021-10-27
Thiol separation (Å)
7
Half-sphere exposure sum ?
82
Minimum pKa ?
12
% buried
100
Peptide A name
Protein inturned
Peptide B name
Fuzzy planar cell polarity protein
Peptide A accession
Q059U7
Peptide B accession
E9QL29
Peptide A residue number
838
Peptide B residue number
365

Ligandability

Cysteine 838 of Protein inturned

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 365 of Fuzzy planar cell polarity protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Fuzzy planar cell polarity protein between cysteines 151 and 309.

Details

Redox score ?
63
PDB code
7q3e
Structure name
structure of the mouse cplane-rsg1 complex
Structure deposition date
2021-10-27
Thiol separation (Å)
5
Half-sphere exposure sum ?
79
Minimum pKa ?
8
% buried
98
Peptide accession
E9QL29
Residue number A
151
Residue number B
309
Peptide name
Fuzzy planar cell polarity protein

Ligandability

Cysteine 151 of Fuzzy planar cell polarity protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 309 of Fuzzy planar cell polarity protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Fuzzy planar cell polarity protein between cysteines 154 and 309. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
7q3e
Structure name
structure of the mouse cplane-rsg1 complex
Structure deposition date
2021-10-27
Thiol separation (Å)
6
Half-sphere exposure sum ?
85
Minimum pKa ?
13
% buried
100
Peptide accession
E9QL29
Residue number A
154
Residue number B
309
Peptide name
Fuzzy planar cell polarity protein

Ligandability

Cysteine 154 of Fuzzy planar cell polarity protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 309 of Fuzzy planar cell polarity protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Fuzzy planar cell polarity protein between cysteines 151 and 154. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
7q3e
Structure name
structure of the mouse cplane-rsg1 complex
Structure deposition date
2021-10-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
82
Minimum pKa ?
8
% buried
98
Peptide accession
E9QL29
Residue number A
151
Residue number B
154
Peptide name
Fuzzy planar cell polarity protein

Ligandability

Cysteine 151 of Fuzzy planar cell polarity protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 154 of Fuzzy planar cell polarity protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Fuzzy planar cell polarity protein between cysteines 247 and 250. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
7q3e
Structure name
structure of the mouse cplane-rsg1 complex
Structure deposition date
2021-10-27
Thiol separation (Å)
10
Half-sphere exposure sum ?
77
Minimum pKa ?
12
% buried
88
Peptide accession
E9QL29
Residue number A
247
Residue number B
250
Peptide name
Fuzzy planar cell polarity protein

Ligandability

Cysteine 247 of Fuzzy planar cell polarity protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 250 of Fuzzy planar cell polarity protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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