V-type proton ATPase subunit a
Intramolecular
Cysteine 24 and cysteine 25
Cysteine 729 and cysteine 732
Cysteine 647 and cysteine 729
Cysteine 310 and cysteine 318
Cysteine 25 and cysteine 310
6xbw a 24 a 25
A redox-regulated disulphide may form within V-type proton ATPase subunit a between cysteines 24 and 25. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
6xbw
Structure name
cryo-em structure of v-atpase from bovine brain, state 1
Structure deposition date
2020-06-07
Thiol separation (Å)
7
Half-sphere exposure sum ?
77
Minimum pKa ?
11
% buried
71
Peptide accession
F1MJV0
Residue number A
24
Residue number B
25
Peptide name
V-type proton ATPase subunit a
Ligandability
Cysteine 24 of V-type proton ATPase subunit a
Cysteine 25 of V-type proton ATPase subunit a
6xbw a 729 a 732
A redox-regulated disulphide may form within V-type proton ATPase subunit a between cysteines 729 and 732. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
6xbw
Structure name
cryo-em structure of v-atpase from bovine brain, state 1
Structure deposition date
2020-06-07
Thiol separation (Å)
8
Half-sphere exposure sum ?
59
Minimum pKa ?
11
% buried
76
Peptide accession
F1MJV0
Residue number A
729
Residue number B
732
Peptide name
V-type proton ATPase subunit a
Ligandability
Cysteine 729 of V-type proton ATPase subunit a
Cysteine 732 of V-type proton ATPase subunit a
6xbw a 647 a 729
A redox-regulated disulphide may form within V-type proton ATPase subunit a between cysteines 647 and 729. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
6xbw
Structure name
cryo-em structure of v-atpase from bovine brain, state 1
Structure deposition date
2020-06-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
59
Minimum pKa ?
11
% buried
46
Peptide accession
F1MJV0
Residue number A
647
Residue number B
729
Peptide name
V-type proton ATPase subunit a
Ligandability
Cysteine 647 of V-type proton ATPase subunit a
Cysteine 729 of V-type proton ATPase subunit a
6xbw a 310 a 318
A redox-regulated disulphide may form within V-type proton ATPase subunit a between cysteines 310 and 318. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
6xbw
Structure name
cryo-em structure of v-atpase from bovine brain, state 1
Structure deposition date
2020-06-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
11
% buried
80
Peptide accession
F1MJV0
Residue number A
310
Residue number B
318
Peptide name
V-type proton ATPase subunit a
Ligandability
Cysteine 310 of V-type proton ATPase subunit a
Cysteine 318 of V-type proton ATPase subunit a
6xby a 25 a 310
A redox-regulated disulphide may form within V-type proton ATPase subunit a between cysteines 25 and 310. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
6xby
Structure name
cryo-em structure of v-atpase from bovine brain, state 2
Structure deposition date
2020-06-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
77
Minimum pKa ?
12
% buried
90
Peptide accession
F1MJV0
Residue number A
25
Residue number B
310
Peptide name
V-type proton ATPase subunit a
Ligandability
Cysteine 25 of V-type proton ATPase subunit a
Cysteine 310 of V-type proton ATPase subunit a
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