ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Glycine receptor alpha 1

Intramolecular
Cysteine 166 and cysteine 180
Cysteine 226 and cysteine 237
A redox-regulated disulphide may form within Glycine receptor alpha 1 between cysteines 166 and 180 (138 and 152 respectively in this structure).

Details

Redox score ?
84
PDB code
7mlv
Structure name
cryo-em reveals partially and fully assembled native glycine receptors,homomeric tetramer
Structure deposition date
2021-04-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
F1RQB7
Residue number A
166
Residue number B
180
Peptide name
Glycine receptor alpha 1

Ligandability

Cysteine 166 of Glycine receptor alpha 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 180 of Glycine receptor alpha 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glycine receptor alpha 1 between cysteines 226 and 237 (198 and 209 respectively in this structure).

Details

Redox score ?
81
PDB code
7mlv
Structure name
cryo-em reveals partially and fully assembled native glycine receptors,homomeric tetramer
Structure deposition date
2021-04-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
F1RQB7
Residue number A
226
Residue number B
237
Peptide name
Glycine receptor alpha 1

Ligandability

Cysteine 226 of Glycine receptor alpha 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 237 of Glycine receptor alpha 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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