ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Voltage dependent anion channel 2

Intermolecular
Cysteine 103 and cysteine 210
Cysteine 47 and cysteine 103
Cysteine 76 and cysteine 47
Intramolecular
Cysteine 13 and cysteine 133
A redox-regulated disulphide may form between two units of Voltage dependent anion channel 2 at cysteines 103 and 210.

Details

Redox score ?
72
PDB code
7nie
Structure name
putative glycerol kinase-like proteins anchored on an array of voltage dependent anion channels in the outer mitochondrial membrane of pig sperm mitochondria
Structure deposition date
2021-02-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
10
% buried
30
Peptide A name
Voltage dependent anion channel 2
Peptide B name
Voltage dependent anion channel 2
Peptide A accession
F1S2F6
Peptide B accession
F1S2F6
Peptide A residue number
103
Peptide B residue number
210

Ligandability

Cysteine 103 of Voltage dependent anion channel 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 210 of Voltage dependent anion channel 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Voltage dependent anion channel 2 at cysteines 47 and 103. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
7nie
Structure name
putative glycerol kinase-like proteins anchored on an array of voltage dependent anion channels in the outer mitochondrial membrane of pig sperm mitochondria
Structure deposition date
2021-02-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
35
Minimum pKa ?
9
% buried
0
Peptide A name
Voltage dependent anion channel 2
Peptide B name
Voltage dependent anion channel 2
Peptide A accession
F1S2F6
Peptide B accession
F1S2F6
Peptide A residue number
47
Peptide B residue number
103

Ligandability

Cysteine 47 of Voltage dependent anion channel 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 103 of Voltage dependent anion channel 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Voltage dependent anion channel 2 at cysteines 76 and 47. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
7nie
Structure name
putative glycerol kinase-like proteins anchored on an array of voltage dependent anion channels in the outer mitochondrial membrane of pig sperm mitochondria
Structure deposition date
2021-02-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
36
Minimum pKa ?
9
% buried
0
Peptide A name
Voltage dependent anion channel 2
Peptide B name
Voltage dependent anion channel 2
Peptide A accession
F1S2F6
Peptide B accession
F1S2F6
Peptide A residue number
76
Peptide B residue number
47

Ligandability

Cysteine 76 of Voltage dependent anion channel 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 47 of Voltage dependent anion channel 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage dependent anion channel 2 between cysteines 13 and 133. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
60
PDB code
7nie
Structure name
putative glycerol kinase-like proteins anchored on an array of voltage dependent anion channels in the outer mitochondrial membrane of pig sperm mitochondria
Structure deposition date
2021-02-12
Thiol separation (Å)
7
Half-sphere exposure sum ?
53
Minimum pKa ?
9
% buried
0
Peptide accession
F1S2F6
Residue number A
13
Residue number B
133
Peptide name
Voltage dependent anion channel 2

Ligandability

Cysteine 13 of Voltage dependent anion channel 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 133 of Voltage dependent anion channel 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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