ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

Intramolecular
Cysteine 69 and cysteine 80
Cysteine 59 and cysteine 90
A redox-regulated disulphide may form within NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 between cysteines 69 and 80.

Details

Redox score ?
75
PDB code
7v2r
Structure name
active state complex i from q1-nadh dataset
Structure deposition date
2021-08-09
Thiol separation (Å)
3
Half-sphere exposure sum ?
63
Minimum pKa ?
10
% buried
44
Peptide accession
F1SCH1
Residue number A
69
Residue number B
80
Peptide name
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

Ligandability

Cysteine 69 of NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

Cysteine 80 of NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

A redox-regulated disulphide may form within NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 between cysteines 59 and 90.

Details

Redox score ?
75
PDB code
7w4g
Structure name
active state ci from q1-nadh dataset, subclass 5
Structure deposition date
2021-11-27
Thiol separation (Å)
3
Half-sphere exposure sum ?
68
Minimum pKa ?
8
% buried
86
Peptide accession
F1SCH1
Residue number A
59
Residue number B
90
Peptide name
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

Ligandability

Cysteine 59 of NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

Cysteine 90 of NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

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