a tool for identifying drug-targetable redox-active disulphides

28S ribosomal protein S35, mitochondrial isoform 1

Intramolecular

Cysteine 166 and cysteine 173

A redox-regulated disulphide may form within 28S ribosomal protein S35, mitochondrial isoform 1 between cysteines 166 and 173 (125 and 132 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

47

PDB code

Structure name

structure of the small subunit of the mammalian mitoribosome

Structure deposition date

2015-02-20

Thiol separation (Å)

8

Half-sphere exposure sum ?

73

Minimum pK_a ?

10

% buried

62

Peptide accession

Residue number A

166

Residue number B

173

Peptide name

28S ribosomal protein S35, mitochondrial isoform 1

Ligandability

Cysteine 166 of 28S ribosomal protein S35, mitochondrial isoform 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 173 of 28S ribosomal protein S35, mitochondrial isoform 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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