ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Mitochondrial ribosomal protein L39

Intramolecular
Cysteine 88 and cysteine 120
Cysteine 143 and cysteine 272
A redox-regulated disulphide may form within Mitochondrial ribosomal protein L39 between cysteines 88 and 120. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
4ce4
Structure name
39s large subunit of the porcine mitochondrial ribosome
Structure deposition date
2013-11-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
10
% buried
45
Peptide accession
F1SHP6
Residue number A
88
Residue number B
120
Peptide name
Mitochondrial ribosomal protein L39

Ligandability

Cysteine 88 of Mitochondrial ribosomal protein L39

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 120 of Mitochondrial ribosomal protein L39

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mitochondrial ribosomal protein L39 between cysteines 143 and 272. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
4ce4
Structure name
39s large subunit of the porcine mitochondrial ribosome
Structure deposition date
2013-11-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
77
Minimum pKa ?
11
% buried
91
Peptide accession
F1SHP6
Residue number A
143
Residue number B
272
Peptide name
Mitochondrial ribosomal protein L39

Ligandability

Cysteine 143 of Mitochondrial ribosomal protein L39

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 272 of Mitochondrial ribosomal protein L39

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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