a tool for identifying drug-targetable redox-active disulphides

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

Intramolecular

Cysteine 255 and cysteine 280

A redox-regulated disulphide may form within NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial between cysteines 255 and 280 (253 and 278 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

57

PDB code

Structure name

deactive state ci from q1-nadh dataset, subclass 4

Structure deposition date

2021-11-28

Thiol separation (Å)

7

Half-sphere exposure sum ?

57

Minimum pK_a ?

10

% buried

36

Peptide accession

Residue number A

255

Residue number B

280

Peptide name

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

Ligandability

Cysteine 255 of NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 280 of NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: