ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Transformation/transcription domain-associated protein

Intermolecular
Cysteine 2639 and cysteine 263 of Transcriptional adapter 1
Intramolecular
Cysteine 1145 and cysteine 1148
Cysteine 1147 and cysteine 1148
Cysteine 3544 and cysteine 3747
Cysteine 930 and cysteine 2485
Cysteine 1342 and cysteine 1407
Cysteine 2639 and cysteine 2673
Cysteine 1098 and cysteine 1107
Cysteine 1145 and cysteine 1147
Cysteine 1107 and cysteine 1147
Cysteine 2477 and cysteine 2656
A redox-regulated disulphide may form between cysteine 2639 of Transformation/transcription domain-associated protein and cysteine 263 of Transcriptional adapter 1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
7ktr
Structure name
cryo-em structure of the human saga coactivator complex (trrap, core)
Structure deposition date
2020-11-24
Thiol separation (Å)
8
Half-sphere exposure sum ?
81
Minimum pKa ?
12
% buried
98
Peptide A name
Transformation/transcription domain-associated protein
Peptide B name
Transcriptional adapter 1
Peptide A accession
F2Z2U4
Peptide B accession
Q96BN2
Peptide A residue number
2639
Peptide B residue number
263

Ligandability

Cysteine 2639 of Transformation/transcription domain-associated protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 263 of Transcriptional adapter 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transformation/transcription domain-associated protein between cysteines 1145 and 1148. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
7ktr
Structure name
cryo-em structure of the human saga coactivator complex (trrap, core)
Structure deposition date
2020-11-24
Thiol separation (Å)
6
Half-sphere exposure sum ?
80
Minimum pKa ?
12
% buried
99
Peptide accession
F2Z2U4
Residue number A
1145
Residue number B
1148
Peptide name
Transformation/transcription domain-associated protein

Ligandability

Cysteine 1145 of Transformation/transcription domain-associated protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1148 of Transformation/transcription domain-associated protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transformation/transcription domain-associated protein between cysteines 1147 and 1148. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
7ktr
Structure name
cryo-em structure of the human saga coactivator complex (trrap, core)
Structure deposition date
2020-11-24
Thiol separation (Å)
7
Half-sphere exposure sum ?
79
Minimum pKa ?
11
% buried
98
Peptide accession
F2Z2U4
Residue number A
1147
Residue number B
1148
Peptide name
Transformation/transcription domain-associated protein

Ligandability

Cysteine 1147 of Transformation/transcription domain-associated protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1148 of Transformation/transcription domain-associated protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transformation/transcription domain-associated protein between cysteines 3544 and 3747. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
7ktr
Structure name
cryo-em structure of the human saga coactivator complex (trrap, core)
Structure deposition date
2020-11-24
Thiol separation (Å)
7
Half-sphere exposure sum ?
69
Minimum pKa ?
11
% buried
92
Peptide accession
F2Z2U4
Residue number A
3544
Residue number B
3747
Peptide name
Transformation/transcription domain-associated protein

Ligandability

Cysteine 3544 of Transformation/transcription domain-associated protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 3747 of Transformation/transcription domain-associated protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transformation/transcription domain-associated protein between cysteines 930 and 2485. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
7ktr
Structure name
cryo-em structure of the human saga coactivator complex (trrap, core)
Structure deposition date
2020-11-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
56
Minimum pKa ?
11
% buried
58
Peptide accession
F2Z2U4
Residue number A
930
Residue number B
2485
Peptide name
Transformation/transcription domain-associated protein

Ligandability

Cysteine 930 of Transformation/transcription domain-associated protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2485 of Transformation/transcription domain-associated protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transformation/transcription domain-associated protein between cysteines 1342 and 1407. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
7ktr
Structure name
cryo-em structure of the human saga coactivator complex (trrap, core)
Structure deposition date
2020-11-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
11
% buried
80
Peptide accession
F2Z2U4
Residue number A
1342
Residue number B
1407
Peptide name
Transformation/transcription domain-associated protein

Ligandability

Cysteine 1342 of Transformation/transcription domain-associated protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1407 of Transformation/transcription domain-associated protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transformation/transcription domain-associated protein between cysteines 2639 and 2673. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
7ktr
Structure name
cryo-em structure of the human saga coactivator complex (trrap, core)
Structure deposition date
2020-11-24
Thiol separation (Å)
8
Half-sphere exposure sum ?
84
Minimum pKa ?
12
% buried
96
Peptide accession
F2Z2U4
Residue number A
2639
Residue number B
2673
Peptide name
Transformation/transcription domain-associated protein

Ligandability

Cysteine 2639 of Transformation/transcription domain-associated protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2673 of Transformation/transcription domain-associated protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transformation/transcription domain-associated protein between cysteines 1098 and 1107. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
7ktr
Structure name
cryo-em structure of the human saga coactivator complex (trrap, core)
Structure deposition date
2020-11-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
76
Minimum pKa ?
10
% buried
80
Peptide accession
F2Z2U4
Residue number A
1098
Residue number B
1107
Peptide name
Transformation/transcription domain-associated protein

Ligandability

Cysteine 1098 of Transformation/transcription domain-associated protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1107 of Transformation/transcription domain-associated protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transformation/transcription domain-associated protein between cysteines 1145 and 1147. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
7ktr
Structure name
cryo-em structure of the human saga coactivator complex (trrap, core)
Structure deposition date
2020-11-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
75
Minimum pKa ?
11
% buried
100
Peptide accession
F2Z2U4
Residue number A
1145
Residue number B
1147
Peptide name
Transformation/transcription domain-associated protein

Ligandability

Cysteine 1145 of Transformation/transcription domain-associated protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1147 of Transformation/transcription domain-associated protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transformation/transcription domain-associated protein between cysteines 1107 and 1147. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
7ktr
Structure name
cryo-em structure of the human saga coactivator complex (trrap, core)
Structure deposition date
2020-11-24
Thiol separation (Å)
10
Half-sphere exposure sum ?
71
Minimum pKa ?
10
% buried
79
Peptide accession
F2Z2U4
Residue number A
1107
Residue number B
1147
Peptide name
Transformation/transcription domain-associated protein

Ligandability

Cysteine 1107 of Transformation/transcription domain-associated protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1147 of Transformation/transcription domain-associated protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transformation/transcription domain-associated protein between cysteines 2477 and 2656. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
27
PDB code
7ktr
Structure name
cryo-em structure of the human saga coactivator complex (trrap, core)
Structure deposition date
2020-11-24
Thiol separation (Å)
10
Half-sphere exposure sum ?
73
Minimum pKa ?
12
% buried
94
Peptide accession
F2Z2U4
Residue number A
2477
Residue number B
2656
Peptide name
Transformation/transcription domain-associated protein

Ligandability

Cysteine 2477 of Transformation/transcription domain-associated protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2656 of Transformation/transcription domain-associated protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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