ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Heterogeneous nuclear ribonucleoprotein L

Intramolecular
Cysteine 264 and cysteine 265
Cysteine 212 and cysteine 215
A redox-regulated disulphide may form within Heterogeneous nuclear ribonucleoprotein L between cysteines 264 and 265 (257 and 258 respectively in this structure).

Details

Redox score ?
63
PDB code
2mqp
Structure name
structural investigation of hnrnp l bound to rna
Structure deposition date
2014-06-24
Thiol separation (Å)
6
Half-sphere exposure sum ?
46
Minimum pKa ?
9
% buried
6
Peptide accession
F2Z3R2
Residue number A
264
Residue number B
265
Peptide name
Heterogeneous nuclear ribonucleoprotein L

Ligandability

Cysteine 264 of Heterogeneous nuclear ribonucleoprotein L

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 265 of Heterogeneous nuclear ribonucleoprotein L

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Heterogeneous nuclear ribonucleoprotein L between cysteines 212 and 215. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
2mqp
Structure name
structural investigation of hnrnp l bound to rna
Structure deposition date
2014-06-24
Thiol separation (Å)
6
Half-sphere exposure sum ?
63
Minimum pKa ?
10
% buried
58
Peptide accession
F2Z3R2
Residue number A
212
Residue number B
215
Peptide name
Heterogeneous nuclear ribonucleoprotein L

Ligandability

Cysteine 212 of Heterogeneous nuclear ribonucleoprotein L

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 215 of Heterogeneous nuclear ribonucleoprotein L

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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