ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ig-like domain-containing protein

Intramolecular
Cysteine 285 and cysteine 343
Cysteine 179 and cysteine 239
A redox-regulated disulphide may form within Ig-like domain-containing protein between cysteines 285 and 343 (367 and 425 respectively in this structure).

Details

Redox score ?
81
PDB code
6d4e
Structure name
crystal structure of a fc fragment of rhesus macaque (macaca mulatta) igg1
Structure deposition date
2018-04-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
F6RL33
Residue number A
285
Residue number B
343
Peptide name
Ig-like domain-containing protein

Ligandability

Cysteine 285 of Ig-like domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 343 of Ig-like domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ig-like domain-containing protein between cysteines 179 and 239 (261 and 321 respectively in this structure).

Details

Redox score ?
80
PDB code
6d4e
Structure name
crystal structure of a fc fragment of rhesus macaque (macaca mulatta) igg1
Structure deposition date
2018-04-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
F6RL33
Residue number A
179
Residue number B
239
Peptide name
Ig-like domain-containing protein

Ligandability

Cysteine 179 of Ig-like domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 239 of Ig-like domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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