ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Solute carrier family 15 member 1

Intramolecular
Cysteine 538 and cysteine 564
Cysteine 189 and cysteine 197
A redox-regulated disulphide may form within Solute carrier family 15 member 1 between cysteines 538 and 564 (539 and 565 respectively in this structure).

Details

Redox score ?
86
PDB code
7s8u
Structure name
cryo-em structure of a mammalian peptide transporter (pept1/slc15a1) in nanodisc
Structure deposition date
2021-09-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide accession
F6SG69
Residue number A
538
Residue number B
564
Peptide name
Solute carrier family 15 member 1

Ligandability

Cysteine 538 of Solute carrier family 15 member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 564 of Solute carrier family 15 member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Solute carrier family 15 member 1 between cysteines 189 and 197 (190 and 198 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
7s8u
Structure name
cryo-em structure of a mammalian peptide transporter (pept1/slc15a1) in nanodisc
Structure deposition date
2021-09-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
45
Minimum pKa ?
9
% buried
27
Peptide accession
F6SG69
Residue number A
189
Residue number B
197
Peptide name
Solute carrier family 15 member 1

Ligandability

Cysteine 189 of Solute carrier family 15 member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 197 of Solute carrier family 15 member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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