ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Monotreme lactation protein

Intramolecular
Cysteine 170 and cysteine 176
Cysteine 131 and cysteine 228
Cysteine 113 and cysteine 122
A redox-regulated disulphide may form within Monotreme lactation protein between cysteines 170 and 176.

Details

Redox score ?
84
PDB code
6b4m
Structure name
structural characterization of a novel monotreme-specific protein from the milk of the platypus
Structure deposition date
2017-09-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A088CNJ7
Residue number A
170
Residue number B
176
Peptide name
Monotreme lactation protein

Ligandability

Cysteine 170 of Monotreme lactation protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 176 of Monotreme lactation protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Monotreme lactation protein between cysteines 131 and 228.

Details

Redox score ?
83
PDB code
4v00
Structure name
structural and functional characterization of a novel monotreme- specific protein from the milk of the platypus
Structure deposition date
2014-09-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
F6UME2
Residue number A
131
Residue number B
228
Peptide name
Monotreme lactation protein

Ligandability

Cysteine 131 of Monotreme lactation protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 228 of Monotreme lactation protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Monotreme lactation protein between cysteines 113 and 122.

Details

Redox score ?
79
PDB code
4v00
Structure name
structural and functional characterization of a novel monotreme- specific protein from the milk of the platypus
Structure deposition date
2014-09-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
F6UME2
Residue number A
113
Residue number B
122
Peptide name
Monotreme lactation protein

Ligandability

Cysteine 113 of Monotreme lactation protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 122 of Monotreme lactation protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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