ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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T-cell surface glycoprotein CD4

Intramolecular
Cysteine 155 and cysteine 184
Cysteine 41 and cysteine 109
A redox-regulated disulphide may form within T-cell surface glycoprotein CD4 between cysteines 155 and 184 (130 and 159 respectively in this structure).

Details

Redox score ?
87
PDB code
6tyb
Structure name
isolation and structure of an antibody that fully neutralizes isolate sivmac239 reveals functional similarity of siv and hiv glycan shields
Structure deposition date
2019-08-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
F6XGD3
Residue number A
155
Residue number B
184
Peptide name
T-cell surface glycoprotein CD4

Ligandability

Cysteine 155 of T-cell surface glycoprotein CD4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 184 of T-cell surface glycoprotein CD4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within T-cell surface glycoprotein CD4 between cysteines 41 and 109 (16 and 84 respectively in this structure).

Details

Redox score ?
82
PDB code
6tyb
Structure name
isolation and structure of an antibody that fully neutralizes isolate sivmac239 reveals functional similarity of siv and hiv glycan shields
Structure deposition date
2019-08-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
F6XGD3
Residue number A
41
Residue number B
109
Peptide name
T-cell surface glycoprotein CD4

Ligandability

Cysteine 41 of T-cell surface glycoprotein CD4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 109 of T-cell surface glycoprotein CD4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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