ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ig-like domain-containing protein

Intramolecular
Cysteine 10 and cysteine 70
Cysteine 116 and cysteine 174
A redox-regulated disulphide may form within Ig-like domain-containing protein between cysteines 10 and 70 (261 and 321 respectively in this structure).

Details

Redox score ?
81
PDB code
6d4i
Structure name
crystal structure of a fc fragment of rhesus macaque (macaca mulatta) igg2
Structure deposition date
2018-04-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
F7H602
Residue number A
10
Residue number B
70
Peptide name
Ig-like domain-containing protein

Ligandability

Cysteine 10 of Ig-like domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 70 of Ig-like domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ig-like domain-containing protein between cysteines 116 and 174 (367 and 425 respectively in this structure).

Details

Redox score ?
80
PDB code
6d4i
Structure name
crystal structure of a fc fragment of rhesus macaque (macaca mulatta) igg2
Structure deposition date
2018-04-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
F7H602
Residue number A
116
Residue number B
174
Peptide name
Ig-like domain-containing protein

Ligandability

Cysteine 116 of Ig-like domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 174 of Ig-like domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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