40S ribosomal protein S12
Intramolecular
Cysteine 50 and cysteine 69
Cysteine 56 and cysteine 108
Cysteine 50 and cysteine 108
Cysteine 69 and cysteine 108
Cysteine 106 and cysteine 108
Cysteine 92 and cysteine 106
Cysteine 56 and cysteine 106
Cysteine 50 and cysteine 106
4kzy M 50 M 69
A redox-regulated disulphide may form within 40S ribosomal protein S12 between cysteines 50 and 69.
Details
Redox score ?
73
PDB code
4kzy
Structure name
rabbit 40s ribosomal subunit in complex with eif1 and eif1a
Structure deposition date
2013-05-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
79
Minimum pKa ?
8
% buried
85
Peptide accession
G1SFR8
Residue number A
50
Residue number B
69
Peptide name
40S ribosomal protein S12
Ligandability
Cysteine 50 of 40S ribosomal protein S12
Cysteine 69 of 40S ribosomal protein S12
4kzy M 56 M 108
A redox-regulated disulphide may form within 40S ribosomal protein S12 between cysteines 56 and 108. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
4kzy
Structure name
rabbit 40s ribosomal subunit in complex with eif1 and eif1a
Structure deposition date
2013-05-30
Thiol separation (Å)
8
Half-sphere exposure sum ?
65
Minimum pKa ?
10
% buried
65
Peptide accession
G1SFR8
Residue number A
56
Residue number B
108
Peptide name
40S ribosomal protein S12
Ligandability
Cysteine 56 of 40S ribosomal protein S12
Cysteine 108 of 40S ribosomal protein S12
4kzx M 50 M 108
A redox-regulated disulphide may form within 40S ribosomal protein S12 between cysteines 50 and 108. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
4kzx
Structure name
rabbit 40s ribosomal subunit in complex with eif1
Structure deposition date
2013-05-30
Thiol separation (Å)
6
Half-sphere exposure sum ?
90
Minimum pKa ?
12
% buried
98
Peptide accession
G1SFR8
Residue number A
50
Residue number B
108
Peptide name
40S ribosomal protein S12
Ligandability
Cysteine 50 of 40S ribosomal protein S12
Cysteine 108 of 40S ribosomal protein S12
4kzy M 69 M 108
A redox-regulated disulphide may form within 40S ribosomal protein S12 between cysteines 69 and 108. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
4kzy
Structure name
rabbit 40s ribosomal subunit in complex with eif1 and eif1a
Structure deposition date
2013-05-30
Thiol separation (Å)
8
Half-sphere exposure sum ?
80
Minimum pKa ?
8
% buried
86
Peptide accession
G1SFR8
Residue number A
69
Residue number B
108
Peptide name
40S ribosomal protein S12
Ligandability
Cysteine 69 of 40S ribosomal protein S12
Cysteine 108 of 40S ribosomal protein S12
4kzz M 106 M 108
A redox-regulated disulphide may form within 40S ribosomal protein S12 between cysteines 106 and 108. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
4kzz
Structure name
rabbit 40s ribosomal subunit in complex with mrna, initiator trna and eif1a
Structure deposition date
2013-05-30
Thiol separation (Å)
7
Half-sphere exposure sum ?
80
Minimum pKa ?
13
% buried
96
Peptide accession
G1SFR8
Residue number A
106
Residue number B
108
Peptide name
40S ribosomal protein S12
Ligandability
Cysteine 106 of 40S ribosomal protein S12
Cysteine 108 of 40S ribosomal protein S12
5k0y r 92 r 106
A redox-regulated disulphide may form within 40S ribosomal protein S12 between cysteines 92 and 106. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
5k0y
Structure name
m48s late-stage initiation complex, purified from rabbit reticulocytes lysates, displaying eif2 ternary complex and eif3 i and g subunits relocated to the intersubunit face
Structure deposition date
2016-05-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
57
Minimum pKa ?
10
% buried
70
Peptide accession
G1SFR8
Residue number A
92
Residue number B
106
Peptide name
40S ribosomal protein S12
Ligandability
Cysteine 92 of 40S ribosomal protein S12
Cysteine 106 of 40S ribosomal protein S12
4d5l M 56 M 106
A redox-regulated disulphide may form within 40S ribosomal protein S12 between cysteines 56 and 106. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
4d5l
Structure name
cryo-em structures of ribosomal 80s complexes with termination factors and cricket paralysis virus ires reveal the ires in the translocated state
Structure deposition date
2014-11-05
Thiol separation (Å)
10
Half-sphere exposure sum ?
59
Minimum pKa ?
10
% buried
71
Peptide accession
G1SFR8
Residue number A
56
Residue number B
106
Peptide name
40S ribosomal protein S12
Ligandability
Cysteine 56 of 40S ribosomal protein S12
Cysteine 106 of 40S ribosomal protein S12
4kzz M 50 M 106
A redox-regulated disulphide may form within 40S ribosomal protein S12 between cysteines 50 and 106. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
30
PDB code
4kzz
Structure name
rabbit 40s ribosomal subunit in complex with mrna, initiator trna and eif1a
Structure deposition date
2013-05-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
80
Minimum pKa ?
12
% buried
94
Peptide accession
G1SFR8
Residue number A
50
Residue number B
106
Peptide name
40S ribosomal protein S12
Ligandability
Cysteine 50 of 40S ribosomal protein S12
Cysteine 106 of 40S ribosomal protein S12
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