ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Glucagon like peptide 1 receptor

Intramolecular
Cysteine 85 and cysteine 126
Cysteine 62 and cysteine 104
Cysteine 226 and cysteine 296
Cysteine 46 and cysteine 71
A redox-regulated disulphide may form within Glucagon like peptide 1 receptor between cysteines 85 and 126.

Details

Redox score ?
88
PDB code
5vai
Structure name
cryo-em structure of the activated glucagon-like peptide-1 receptor in complex with g protein
Structure deposition date
2017-03-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
G1SGD4
Residue number A
85
Residue number B
126
Peptide name
Glucagon like peptide 1 receptor

Ligandability

Cysteine 85 of Glucagon like peptide 1 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 126 of Glucagon like peptide 1 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glucagon like peptide 1 receptor between cysteines 62 and 104.

Details

Redox score ?
85
PDB code
5vai
Structure name
cryo-em structure of the activated glucagon-like peptide-1 receptor in complex with g protein
Structure deposition date
2017-03-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
G1SGD4
Residue number A
62
Residue number B
104
Peptide name
Glucagon like peptide 1 receptor

Ligandability

Cysteine 62 of Glucagon like peptide 1 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 104 of Glucagon like peptide 1 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glucagon like peptide 1 receptor between cysteines 226 and 296.

Details

Redox score ?
83
PDB code
5vai
Structure name
cryo-em structure of the activated glucagon-like peptide-1 receptor in complex with g protein
Structure deposition date
2017-03-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
G1SGD4
Residue number A
226
Residue number B
296
Peptide name
Glucagon like peptide 1 receptor

Ligandability

Cysteine 226 of Glucagon like peptide 1 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 296 of Glucagon like peptide 1 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glucagon like peptide 1 receptor between cysteines 46 and 71.

Details

Redox score ?
80
PDB code
5vai
Structure name
cryo-em structure of the activated glucagon-like peptide-1 receptor in complex with g protein
Structure deposition date
2017-03-27
Thiol separation (Å)
3
Half-sphere exposure sum ?
63
Minimum pKa ?
9
% buried
18
Peptide accession
G1SGD4
Residue number A
46
Residue number B
71
Peptide name
Glucagon like peptide 1 receptor

Ligandability

Cysteine 46 of Glucagon like peptide 1 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 71 of Glucagon like peptide 1 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: