a tool for identifying drug-targetable redox-active disulphides

40S ribosomal protein S20

Intermolecular

Cysteine 70 and cysteine 39 of 40S ribosomal protein S29

A redox-regulated disulphide may form between cysteine 70 of 40S ribosomal protein S20 and cysteine 39 of 40S ribosomal protein S29. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

38

PDB code

Structure name

rabbit 40s ribosomal subunit in complex with eif1 and eif1a

Structure deposition date

2013-05-30

Thiol separation (Å)

9

Half-sphere exposure sum ?

50

Minimum pK_a ?

10

% buried

100

Peptide A name

40S ribosomal protein S20

Peptide B name

40S ribosomal protein S29

Peptide A accession

Peptide B accession

Peptide A residue number

70

Peptide B residue number

39

Ligandability

Cysteine 70 of 40S ribosomal protein S20

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 39 of 40S ribosomal protein S29

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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