ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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WD_REPEATS_REGION domain-containing protein

Intramolecular
Cysteine 260 and cysteine 275
Cysteine 245 and cysteine 289
Cysteine 356 and cysteine 393
Cysteine 347 and cysteine 356
Cysteine 275 and cysteine 314
Cysteine 260 and cysteine 314
Cysteine 347 and cysteine 393
Cysteine 260 and cysteine 347
A redox-regulated disulphide may form within WD_REPEATS_REGION domain-containing protein between cysteines 260 and 275 (153 and 168 respectively in this structure).

Details

Redox score ?
62
PDB code
4kzy
Structure name
rabbit 40s ribosomal subunit in complex with eif1 and eif1a
Structure deposition date
2013-05-30
Thiol separation (Å)
5
Half-sphere exposure sum ?
101
Minimum pKa ?
6
% buried
100
Peptide accession
G1SJB4
Residue number A
260
Residue number B
275
Peptide name
WD_REPEATS_REGION domain-containing protein

Ligandability

Cysteine 260 of WD_REPEATS_REGION domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 275 of WD_REPEATS_REGION domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD_REPEATS_REGION domain-containing protein between cysteines 245 and 289 (138 and 182 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
4kzy
Structure name
rabbit 40s ribosomal subunit in complex with eif1 and eif1a
Structure deposition date
2013-05-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
46
Minimum pKa ?
9
% buried
26
Peptide accession
G1SJB4
Residue number A
245
Residue number B
289
Peptide name
WD_REPEATS_REGION domain-containing protein

Ligandability

Cysteine 245 of WD_REPEATS_REGION domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 289 of WD_REPEATS_REGION domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD_REPEATS_REGION domain-containing protein between cysteines 356 and 393 (249 and 286 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
4kzx
Structure name
rabbit 40s ribosomal subunit in complex with eif1
Structure deposition date
2013-05-30
Thiol separation (Å)
7
Half-sphere exposure sum ?
88
Minimum pKa ?
13
% buried
100
Peptide accession
G1SJB4
Residue number A
356
Residue number B
393
Peptide name
WD_REPEATS_REGION domain-containing protein

Ligandability

Cysteine 356 of WD_REPEATS_REGION domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 393 of WD_REPEATS_REGION domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD_REPEATS_REGION domain-containing protein between cysteines 347 and 356 (240 and 249 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
4kzx
Structure name
rabbit 40s ribosomal subunit in complex with eif1
Structure deposition date
2013-05-30
Thiol separation (Å)
7
Half-sphere exposure sum ?
87
Minimum pKa ?
11
% buried
100
Peptide accession
G1SJB4
Residue number A
347
Residue number B
356
Peptide name
WD_REPEATS_REGION domain-containing protein

Ligandability

Cysteine 347 of WD_REPEATS_REGION domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 356 of WD_REPEATS_REGION domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD_REPEATS_REGION domain-containing protein between cysteines 275 and 314 (168 and 207 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
7syh
Structure name
structure of the hcv ires binding to the 40s ribosomal subunit, closed conformation
Structure deposition date
2021-11-25
Thiol separation (Å)
8
Half-sphere exposure sum ?
91
Minimum pKa ?
12
% buried
100
Peptide accession
G1SJB4
Residue number A
275
Residue number B
314
Peptide name
WD_REPEATS_REGION domain-containing protein

Ligandability

Cysteine 275 of WD_REPEATS_REGION domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 314 of WD_REPEATS_REGION domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD_REPEATS_REGION domain-containing protein between cysteines 260 and 314 (153 and 207 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
6p4h
Structure name
structure of a mammalian small ribosomal subunit in complex with the israeli acute paralysis virus ires (class 2)
Structure deposition date
2019-05-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
92
Minimum pKa ?
10
% buried
100
Peptide accession
G1SJB4
Residue number A
260
Residue number B
314
Peptide name
WD_REPEATS_REGION domain-containing protein

Ligandability

Cysteine 260 of WD_REPEATS_REGION domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 314 of WD_REPEATS_REGION domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD_REPEATS_REGION domain-containing protein between cysteines 347 and 393 (240 and 286 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
7syl
Structure name
structure of the hcv ires bound to the 40s ribosomal subunit, closed conformation
Structure deposition date
2021-11-25
Thiol separation (Å)
9
Half-sphere exposure sum ?
80
Minimum pKa ?
12
% buried
99
Peptide accession
G1SJB4
Residue number A
347
Residue number B
393
Peptide name
WD_REPEATS_REGION domain-containing protein

Ligandability

Cysteine 347 of WD_REPEATS_REGION domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 393 of WD_REPEATS_REGION domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD_REPEATS_REGION domain-containing protein between cysteines 260 and 347 (153 and 240 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
26
PDB code
7syx
Structure name
structure of the delta dii ires eif5b-containing 48s initiation complex, closed conformation
Structure deposition date
2021-11-25
Thiol separation (Å)
10
Half-sphere exposure sum ?
83
Minimum pKa ?
10
% buried
100
Peptide accession
G1SJB4
Residue number A
260
Residue number B
347
Peptide name
WD_REPEATS_REGION domain-containing protein

Ligandability

Cysteine 260 of WD_REPEATS_REGION domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 347 of WD_REPEATS_REGION domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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