ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Transient receptor potential cation channel subfamily V member 2

Intramolecular
Cysteine 248 and cysteine 259
Cysteine 757 and cysteine 777
Cysteine 173 and cysteine 188
A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily V member 2 between cysteines 248 and 259 (193 and 204 respectively in this structure).

Details

Redox score ?
94
PDB code
5an8
Structure name
cryo-electron microscopy structure of rabbit trpv2 ion channel
Structure deposition date
2015-09-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
G1SNM3
Residue number A
248
Residue number B
259
Peptide name
Transient receptor potential cation channel subfamily V member 2

Ligandability

Cysteine 248 of Transient receptor potential cation channel subfamily V member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 259 of Transient receptor potential cation channel subfamily V member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily V member 2 between cysteines 757 and 777 (702 and 722 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
6oo7
Structure name
cryo-em structure of the c2-symmetric trpv2/rtx complex in nanodiscs
Structure deposition date
2019-04-22
Thiol separation (Å)
10
Half-sphere exposure sum ?
54
Minimum pKa ?
10
% buried
34
Peptide accession
G1SNM3
Residue number A
757
Residue number B
777
Peptide name
Transient receptor potential cation channel subfamily V member 2

Ligandability

Cysteine 757 of Transient receptor potential cation channel subfamily V member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 777 of Transient receptor potential cation channel subfamily V member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily V member 2 between cysteines 173 and 188 (118 and 133 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
6bwm
Structure name
crystal structure of the trpv2 ion channel
Structure deposition date
2017-12-15
Thiol separation (Å)
10
Half-sphere exposure sum ?
80
Minimum pKa ?
11
% buried
68
Peptide accession
G1SNM3
Residue number A
173
Residue number B
188
Peptide name
Transient receptor potential cation channel subfamily V member 2

Ligandability

Cysteine 173 of Transient receptor potential cation channel subfamily V member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 188 of Transient receptor potential cation channel subfamily V member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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