ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Eukaryotic translation initiation factor 2 subunit 1

Intramolecular
Cysteine 70 and cysteine 98
A redox-regulated disulphide may form within Eukaryotic translation initiation factor 2 subunit 1 between cysteines 70 and 98.

Details

Redox score ?
77
PDB code
5k0y
Structure name
m48s late-stage initiation complex, purified from rabbit reticulocytes lysates, displaying eif2 ternary complex and eif3 i and g subunits relocated to the intersubunit face
Structure deposition date
2016-05-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
64
Minimum pKa ?
7
% buried
48
Peptide accession
G1T2G4
Residue number A
70
Residue number B
98
Peptide name
Eukaryotic translation initiation factor 2 subunit 1

Ligandability

Cysteine 70 of Eukaryotic translation initiation factor 2 subunit 1

Cysteine 98 of Eukaryotic translation initiation factor 2 subunit 1

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