ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

40S ribosomal protein S26

Intramolecular
Cysteine 28 and cysteine 74
Cysteine 23 and cysteine 74
Cysteine 26 and cysteine 74
Cysteine 74 and cysteine 77
Cysteine 23 and cysteine 28
Cysteine 28 and cysteine 29
Cysteine 26 and cysteine 28
Cysteine 23 and cysteine 26
Cysteine 26 and cysteine 77
Cysteine 29 and cysteine 74
More...
Cysteine 23 and cysteine 29
Cysteine 26 and cysteine 29
Cysteine 28 and cysteine 77
Cysteine 23 and cysteine 77
A redox-regulated disulphide may form within 40S ribosomal protein S26 between cysteines 28 and 74.

Details

Redox score ?
81
PDB code
4kzy
Structure name
rabbit 40s ribosomal subunit in complex with eif1 and eif1a
Structure deposition date
2013-05-30
Thiol separation (Å)
3
Half-sphere exposure sum ?
68
Minimum pKa ?
5
% buried
100
Peptide accession
G1TFE8
Residue number A
28
Residue number B
74
Peptide name
40S ribosomal protein S26

Ligandability

Cysteine 28 of 40S ribosomal protein S26

Cysteine 74 of 40S ribosomal protein S26

A redox-regulated disulphide may form within 40S ribosomal protein S26 between cysteines 23 and 74.

Details

Redox score ?
81
PDB code
4kzz
Structure name
rabbit 40s ribosomal subunit in complex with mrna, initiator trna and eif1a
Structure deposition date
2013-05-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
74
Minimum pKa ?
5
% buried
nan
Peptide accession
G1TFE8
Residue number A
23
Residue number B
74
Peptide name
40S ribosomal protein S26

Ligandability

Cysteine 23 of 40S ribosomal protein S26

Cysteine 74 of 40S ribosomal protein S26

A redox-regulated disulphide may form within 40S ribosomal protein S26 between cysteines 26 and 74.

Details

Redox score ?
81
PDB code
4kzz
Structure name
rabbit 40s ribosomal subunit in complex with mrna, initiator trna and eif1a
Structure deposition date
2013-05-30
Thiol separation (Å)
3
Half-sphere exposure sum ?
67
Minimum pKa ?
5
% buried
100
Peptide accession
G1TFE8
Residue number A
26
Residue number B
74
Peptide name
40S ribosomal protein S26

Ligandability

Cysteine 26 of 40S ribosomal protein S26

Cysteine 74 of 40S ribosomal protein S26

A redox-regulated disulphide may form within 40S ribosomal protein S26 between cysteines 74 and 77.

Details

Redox score ?
79
PDB code
4kzy
Structure name
rabbit 40s ribosomal subunit in complex with eif1 and eif1a
Structure deposition date
2013-05-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
5
% buried
90
Peptide accession
G1TFE8
Residue number A
74
Residue number B
77
Peptide name
40S ribosomal protein S26

Ligandability

Cysteine 74 of 40S ribosomal protein S26

Cysteine 77 of 40S ribosomal protein S26

A redox-regulated disulphide may form within 40S ribosomal protein S26 between cysteines 23 and 28. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
4kzy
Structure name
rabbit 40s ribosomal subunit in complex with eif1 and eif1a
Structure deposition date
2013-05-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
68
Minimum pKa ?
20
% buried
nan
Peptide accession
G1TFE8
Residue number A
23
Residue number B
28
Peptide name
40S ribosomal protein S26

Ligandability

Cysteine 23 of 40S ribosomal protein S26

Cysteine 28 of 40S ribosomal protein S26

A redox-regulated disulphide may form within 40S ribosomal protein S26 between cysteines 28 and 29. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
4kzz
Structure name
rabbit 40s ribosomal subunit in complex with mrna, initiator trna and eif1a
Structure deposition date
2013-05-30
Thiol separation (Å)
7
Half-sphere exposure sum ?
63
Minimum pKa ?
9
% buried
100
Peptide accession
G1TFE8
Residue number A
28
Residue number B
29
Peptide name
40S ribosomal protein S26

Ligandability

Cysteine 28 of 40S ribosomal protein S26

Cysteine 29 of 40S ribosomal protein S26

A redox-regulated disulphide may form within 40S ribosomal protein S26 between cysteines 26 and 28. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
4kzz
Structure name
rabbit 40s ribosomal subunit in complex with mrna, initiator trna and eif1a
Structure deposition date
2013-05-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
21
% buried
100
Peptide accession
G1TFE8
Residue number A
26
Residue number B
28
Peptide name
40S ribosomal protein S26

Ligandability

Cysteine 26 of 40S ribosomal protein S26

Cysteine 28 of 40S ribosomal protein S26

A redox-regulated disulphide may form within 40S ribosomal protein S26 between cysteines 23 and 26. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
4kzy
Structure name
rabbit 40s ribosomal subunit in complex with eif1 and eif1a
Structure deposition date
2013-05-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
24
% buried
nan
Peptide accession
G1TFE8
Residue number A
23
Residue number B
26
Peptide name
40S ribosomal protein S26

Ligandability

Cysteine 23 of 40S ribosomal protein S26

Cysteine 26 of 40S ribosomal protein S26

A redox-regulated disulphide may form within 40S ribosomal protein S26 between cysteines 26 and 77. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
4kzz
Structure name
rabbit 40s ribosomal subunit in complex with mrna, initiator trna and eif1a
Structure deposition date
2013-05-30
Thiol separation (Å)
3
Half-sphere exposure sum ?
60
Minimum pKa ?
25
% buried
100
Peptide accession
G1TFE8
Residue number A
26
Residue number B
77
Peptide name
40S ribosomal protein S26

Ligandability

Cysteine 26 of 40S ribosomal protein S26

Cysteine 77 of 40S ribosomal protein S26

A redox-regulated disulphide may form within 40S ribosomal protein S26 between cysteines 29 and 74. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
4kzz
Structure name
rabbit 40s ribosomal subunit in complex with mrna, initiator trna and eif1a
Structure deposition date
2013-05-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
5
% buried
100
Peptide accession
G1TFE8
Residue number A
29
Residue number B
74
Peptide name
40S ribosomal protein S26

Ligandability

Cysteine 29 of 40S ribosomal protein S26

Cysteine 74 of 40S ribosomal protein S26

A redox-regulated disulphide may form within 40S ribosomal protein S26 between cysteines 23 and 29. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
7jqc
Structure name
sars-cov-2 nsp1, crpv ires and rabbit 40s ribosome complex
Structure deposition date
2020-08-10
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
7
% buried
94
Peptide accession
G1TFE8
Residue number A
23
Residue number B
29
Peptide name
40S ribosomal protein S26

Ligandability

Cysteine 23 of 40S ribosomal protein S26

Cysteine 29 of 40S ribosomal protein S26

A redox-regulated disulphide may form within 40S ribosomal protein S26 between cysteines 26 and 29. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
7jqb
Structure name
sars-cov-2 nsp1 and rabbit 40s ribosome complex
Structure deposition date
2020-08-10
Thiol separation (Å)
10
Half-sphere exposure sum ?
61
Minimum pKa ?
7
% buried
98
Peptide accession
G1TFE8
Residue number A
26
Residue number B
29
Peptide name
40S ribosomal protein S26

Ligandability

Cysteine 26 of 40S ribosomal protein S26

Cysteine 29 of 40S ribosomal protein S26

A redox-regulated disulphide may form within 40S ribosomal protein S26 between cysteines 28 and 77. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
4kzy
Structure name
rabbit 40s ribosomal subunit in complex with eif1 and eif1a
Structure deposition date
2013-05-30
Thiol separation (Å)
6
Half-sphere exposure sum ?
61
Minimum pKa ?
20
% buried
90
Peptide accession
G1TFE8
Residue number A
28
Residue number B
77
Peptide name
40S ribosomal protein S26

Ligandability

Cysteine 28 of 40S ribosomal protein S26

Cysteine 77 of 40S ribosomal protein S26

A redox-regulated disulphide may form within 40S ribosomal protein S26 between cysteines 23 and 77. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
4kzz
Structure name
rabbit 40s ribosomal subunit in complex with mrna, initiator trna and eif1a
Structure deposition date
2013-05-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
29
% buried
nan
Peptide accession
G1TFE8
Residue number A
23
Residue number B
77
Peptide name
40S ribosomal protein S26

Ligandability

Cysteine 23 of 40S ribosomal protein S26

Cysteine 77 of 40S ribosomal protein S26

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