ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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40S ribosomal protein S8

Intramolecular
Cysteine 71 and cysteine 72
Cysteine 100 and cysteine 174
A redox-regulated disulphide may form within 40S ribosomal protein S8 between cysteines 71 and 72. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
4kzz
Structure name
rabbit 40s ribosomal subunit in complex with mrna, initiator trna and eif1a
Structure deposition date
2013-05-30
Thiol separation (Å)
7
Half-sphere exposure sum ?
35
Minimum pKa ?
10
% buried
78
Peptide accession
G1TJW1
Residue number A
71
Residue number B
72
Peptide name
40S ribosomal protein S8

Ligandability

Cysteine 71 of 40S ribosomal protein S8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 72 of 40S ribosomal protein S8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 40S ribosomal protein S8 between cysteines 100 and 174. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
4kzy
Structure name
rabbit 40s ribosomal subunit in complex with eif1 and eif1a
Structure deposition date
2013-05-30
Thiol separation (Å)
8
Half-sphere exposure sum ?
85
Minimum pKa ?
12
% buried
100
Peptide accession
G1TJW1
Residue number A
100
Residue number B
174
Peptide name
40S ribosomal protein S8

Ligandability

Cysteine 100 of 40S ribosomal protein S8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 174 of 40S ribosomal protein S8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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