ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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40S ribosomal protein S6

Intramolecular
Cysteine 93 and cysteine 110
A redox-regulated disulphide may form within 40S ribosomal protein S6 between cysteines 93 and 110 (83 and 100 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
4kzy
Structure name
rabbit 40s ribosomal subunit in complex with eif1 and eif1a
Structure deposition date
2013-05-30
Thiol separation (Å)
8
Half-sphere exposure sum ?
65
Minimum pKa ?
12
% buried
95
Peptide accession
G1TM55
Residue number A
93
Residue number B
110
Peptide name
40S ribosomal protein S6

Ligandability

Cysteine 93 of 40S ribosomal protein S6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of 40S ribosomal protein S6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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