a tool for identifying drug-targetable redox-active disulphides

40S ribosomal protein S21

Intramolecular

Cysteine 40 and cysteine 79

A redox-regulated disulphide may form within 40S ribosomal protein S21 between cysteines 40 and 79 (17 and 56 respectively in this structure).

Details

Redox score ?

74

PDB code

Structure name

rabbit 40s ribosomal subunit in complex with eif1 and eif1a

Structure deposition date

2013-05-30

Thiol separation (Å)

3

Half-sphere exposure sum ?

80

Minimum pK_a ?

7

% buried

100

Peptide accession

Residue number A

40

Residue number B

79

Peptide name

40S ribosomal protein S21

Ligandability

Cysteine 40 of 40S ribosomal protein S21

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 79 of 40S ribosomal protein S21

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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