ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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40S ribosomal protein S3

Intramolecular
Cysteine 157 and cysteine 172
A redox-regulated disulphide may form within 40S ribosomal protein S3 between cysteines 157 and 172 (119 and 134 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
7syl
Structure name
structure of the hcv ires bound to the 40s ribosomal subunit, closed conformation
Structure deposition date
2021-11-25
Thiol separation (Å)
10
Half-sphere exposure sum ?
72
Minimum pKa ?
11
% buried
69
Peptide accession
G1TNM3
Residue number A
157
Residue number B
172
Peptide name
40S ribosomal protein S3

Ligandability

Cysteine 157 of 40S ribosomal protein S3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 172 of 40S ribosomal protein S3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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