ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Eukaryotic translation initiation factor 5B

Intramolecular
Cysteine 679 and cysteine 764
Cysteine 764 and cysteine 793
Cysteine 679 and cysteine 793
A redox-regulated disulphide may form within Eukaryotic translation initiation factor 5B between cysteines 679 and 764 (633 and 718 respectively in this structure).

Details

Redox score ?
82
PDB code
7syx
Structure name
structure of the delta dii ires eif5b-containing 48s initiation complex, closed conformation
Structure deposition date
2021-11-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
G1TRL5
Residue number A
679
Residue number B
764
Peptide name
Eukaryotic translation initiation factor 5B

Ligandability

Cysteine 679 of Eukaryotic translation initiation factor 5B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 764 of Eukaryotic translation initiation factor 5B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Eukaryotic translation initiation factor 5B between cysteines 764 and 793 (718 and 747 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
7syv
Structure name
structure of the wt ires eif5b-containing pre-48s initiation complex, open conformation
Structure deposition date
2021-11-25
Thiol separation (Å)
7
Half-sphere exposure sum ?
64
Minimum pKa ?
10
% buried
nan
Peptide accession
G1TRL5
Residue number A
764
Residue number B
793
Peptide name
Eukaryotic translation initiation factor 5B

Ligandability

Cysteine 764 of Eukaryotic translation initiation factor 5B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 793 of Eukaryotic translation initiation factor 5B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Eukaryotic translation initiation factor 5B between cysteines 679 and 793 (633 and 747 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
7syv
Structure name
structure of the wt ires eif5b-containing pre-48s initiation complex, open conformation
Structure deposition date
2021-11-25
Thiol separation (Å)
8
Half-sphere exposure sum ?
66
Minimum pKa ?
10
% buried
nan
Peptide accession
G1TRL5
Residue number A
679
Residue number B
793
Peptide name
Eukaryotic translation initiation factor 5B

Ligandability

Cysteine 679 of Eukaryotic translation initiation factor 5B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 793 of Eukaryotic translation initiation factor 5B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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