ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

40S ribosomal protein S29

Intermolecular
Cysteine 70 of 40S ribosomal protein S20 and cysteine 39
Intramolecular
Cysteine 21 and cysteine 24
Cysteine 21 and cysteine 39
Cysteine 21 and cysteine 42
Cysteine 24 and cysteine 39
Cysteine 39 and cysteine 42
Cysteine 24 and cysteine 42
A redox-regulated disulphide may form between cysteine 70 of 40S ribosomal protein S20 and cysteine 39 of 40S ribosomal protein S29. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
4kzy
Structure name
rabbit 40s ribosomal subunit in complex with eif1 and eif1a
Structure deposition date
2013-05-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
50
Minimum pKa ?
10
% buried
100
Peptide A name
40S ribosomal protein S20
Peptide B name
40S ribosomal protein S29
Peptide A accession
G1SIZ2
Peptide B accession
G1U7M4
Peptide A residue number
70
Peptide B residue number
39

Ligandability

Cysteine 70 of 40S ribosomal protein S20

Cysteine 39 of 40S ribosomal protein S29

A redox-regulated disulphide may form within 40S ribosomal protein S29 between cysteines 21 and 24.

Details

Redox score ?
93
PDB code
4kzx
Structure name
rabbit 40s ribosomal subunit in complex with eif1
Structure deposition date
2013-05-30
Thiol separation (Å)
3
Half-sphere exposure sum ?
53
Minimum pKa ?
0
% buried
100
Peptide accession
G1U7M4
Residue number A
21
Residue number B
24
Peptide name
40S ribosomal protein S29

Ligandability

Cysteine 21 of 40S ribosomal protein S29

Cysteine 24 of 40S ribosomal protein S29

A redox-regulated disulphide may form within 40S ribosomal protein S29 between cysteines 21 and 39.

Details

Redox score ?
88
PDB code
4kzx
Structure name
rabbit 40s ribosomal subunit in complex with eif1
Structure deposition date
2013-05-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
0
% buried
100
Peptide accession
G1U7M4
Residue number A
21
Residue number B
39
Peptide name
40S ribosomal protein S29

Ligandability

Cysteine 21 of 40S ribosomal protein S29

Cysteine 39 of 40S ribosomal protein S29

A redox-regulated disulphide may form within 40S ribosomal protein S29 between cysteines 21 and 42.

Details

Redox score ?
88
PDB code
4kzx
Structure name
rabbit 40s ribosomal subunit in complex with eif1
Structure deposition date
2013-05-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
0
% buried
100
Peptide accession
G1U7M4
Residue number A
21
Residue number B
42
Peptide name
40S ribosomal protein S29

Ligandability

Cysteine 21 of 40S ribosomal protein S29

Cysteine 42 of 40S ribosomal protein S29

A redox-regulated disulphide may form within 40S ribosomal protein S29 between cysteines 24 and 39.

Details

Redox score ?
68
PDB code
4kzy
Structure name
rabbit 40s ribosomal subunit in complex with eif1 and eif1a
Structure deposition date
2013-05-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
58
Minimum pKa ?
10
% buried
100
Peptide accession
G1U7M4
Residue number A
24
Residue number B
39
Peptide name
40S ribosomal protein S29

Ligandability

Cysteine 24 of 40S ribosomal protein S29

Cysteine 39 of 40S ribosomal protein S29

A redox-regulated disulphide may form within 40S ribosomal protein S29 between cysteines 39 and 42. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
6p4h
Structure name
structure of a mammalian small ribosomal subunit in complex with the israeli acute paralysis virus ires (class 2)
Structure deposition date
2019-05-27
Thiol separation (Å)
3
Half-sphere exposure sum ?
63
Minimum pKa ?
17
% buried
nan
Peptide accession
G1U7M4
Residue number A
39
Residue number B
42
Peptide name
40S ribosomal protein S29

Ligandability

Cysteine 39 of 40S ribosomal protein S29

Cysteine 42 of 40S ribosomal protein S29

A redox-regulated disulphide may form within 40S ribosomal protein S29 between cysteines 24 and 42. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
4kzx
Structure name
rabbit 40s ribosomal subunit in complex with eif1
Structure deposition date
2013-05-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
19
% buried
100
Peptide accession
G1U7M4
Residue number A
24
Residue number B
42
Peptide name
40S ribosomal protein S29

Ligandability

Cysteine 24 of 40S ribosomal protein S29

Cysteine 42 of 40S ribosomal protein S29

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