ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Legumain

Intramolecular
Cysteine 395 and cysteine 434
Cysteine 383 and cysteine 417
A redox-regulated disulphide may form within Legumain between cysteines 395 and 434.

Details

Redox score ?
86
PDB code
4d3y
Structure name
the structure of inactive prolegumain from chinese hamster
Structure deposition date
2014-10-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
G3I1H5
Residue number A
395
Residue number B
434
Peptide name
Legumain

Ligandability

Cysteine 395 of Legumain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 434 of Legumain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Legumain between cysteines 383 and 417.

Details

Redox score ?
83
PDB code
4d3y
Structure name
the structure of inactive prolegumain from chinese hamster
Structure deposition date
2014-10-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
G3I1H5
Residue number A
383
Residue number B
417
Peptide name
Legumain

Ligandability

Cysteine 383 of Legumain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 417 of Legumain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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