ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

UbiA prenyltransferase domain-containing protein 1

Intramolecular
Cysteine 145 and cysteine 148
Cysteine 143 and cysteine 145
Cysteine 87 and cysteine 145
A redox-regulated disulphide may form within UbiA prenyltransferase domain-containing protein 1 between cysteines 145 and 148. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
8djm
Structure name
hmgcr-ubiad1 complex state 1
Structure deposition date
2022-07-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
53
Minimum pKa ?
9
% buried
20
Peptide accession
G3IEF0
Residue number A
145
Residue number B
148
Peptide name
UbiA prenyltransferase domain-containing protein 1

Ligandability

Cysteine 145 of UbiA prenyltransferase domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 148 of UbiA prenyltransferase domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within UbiA prenyltransferase domain-containing protein 1 between cysteines 143 and 145. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
8djk
Structure name
hmgcr-ubiad1 complex state 2
Structure deposition date
2022-06-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
10
% buried
58
Peptide accession
G3IEF0
Residue number A
143
Residue number B
145
Peptide name
UbiA prenyltransferase domain-containing protein 1

Ligandability

Cysteine 143 of UbiA prenyltransferase domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 145 of UbiA prenyltransferase domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within UbiA prenyltransferase domain-containing protein 1 between cysteines 87 and 145. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
8djk
Structure name
hmgcr-ubiad1 complex state 2
Structure deposition date
2022-06-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
77
Minimum pKa ?
10
% buried
66
Peptide accession
G3IEF0
Residue number A
87
Residue number B
145
Peptide name
UbiA prenyltransferase domain-containing protein 1

Ligandability

Cysteine 87 of UbiA prenyltransferase domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 145 of UbiA prenyltransferase domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: