ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Sodium/potassium-transporting ATPase subunit beta

Intramolecular
Cysteine 126 and cysteine 149
Cysteine 159 and cysteine 175
Cysteine 213 and cysteine 276
A redox-regulated disulphide may form within Sodium/potassium-transporting ATPase subunit beta between cysteines 126 and 149.

Details

Redox score ?
84
PDB code
4xe5
Structure name
crystal structure of the na,k-atpase from bovine
Structure deposition date
2014-12-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
G3MWR4
Residue number A
126
Residue number B
149
Peptide name
Sodium/potassium-transporting ATPase subunit beta

Ligandability

Cysteine 126 of Sodium/potassium-transporting ATPase subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 149 of Sodium/potassium-transporting ATPase subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium/potassium-transporting ATPase subunit beta between cysteines 159 and 175.

Details

Redox score ?
83
PDB code
4xe5
Structure name
crystal structure of the na,k-atpase from bovine
Structure deposition date
2014-12-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
G3MWR4
Residue number A
159
Residue number B
175
Peptide name
Sodium/potassium-transporting ATPase subunit beta

Ligandability

Cysteine 159 of Sodium/potassium-transporting ATPase subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 175 of Sodium/potassium-transporting ATPase subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium/potassium-transporting ATPase subunit beta between cysteines 213 and 276.

Details

Redox score ?
82
PDB code
4xe5
Structure name
crystal structure of the na,k-atpase from bovine
Structure deposition date
2014-12-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
G3MWR4
Residue number A
213
Residue number B
276
Peptide name
Sodium/potassium-transporting ATPase subunit beta

Ligandability

Cysteine 213 of Sodium/potassium-transporting ATPase subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 276 of Sodium/potassium-transporting ATPase subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: