ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ceruloplasmin

Intramolecular
Cysteine 631 and cysteine 712
Cysteine 275 and cysteine 356
Cysteine 528 and cysteine 554
Cysteine 173 and cysteine 199
Cysteine 868 and cysteine 894
A redox-regulated disulphide may form within Ceruloplasmin between cysteines 631 and 712 (612 and 693 respectively in this structure).

Details

Redox score ?
83
PDB code
5n4l
Structure name
rat ceruloplasmin trigonal form
Structure deposition date
2017-02-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
40
Minimum pKa ?
nan
% buried
nan
Peptide accession
G3V7K3
Residue number A
631
Residue number B
712
Peptide name
Ceruloplasmin

Ligandability

Cysteine 631 of Ceruloplasmin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 712 of Ceruloplasmin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ceruloplasmin between cysteines 275 and 356 (256 and 337 respectively in this structure).

Details

Redox score ?
81
PDB code
5n4l
Structure name
rat ceruloplasmin trigonal form
Structure deposition date
2017-02-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
G3V7K3
Residue number A
275
Residue number B
356
Peptide name
Ceruloplasmin

Ligandability

Cysteine 275 of Ceruloplasmin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 356 of Ceruloplasmin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ceruloplasmin between cysteines 528 and 554 (509 and 535 respectively in this structure).

Details

Redox score ?
80
PDB code
5n4l
Structure name
rat ceruloplasmin trigonal form
Structure deposition date
2017-02-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
G3V7K3
Residue number A
528
Residue number B
554
Peptide name
Ceruloplasmin

Ligandability

Cysteine 528 of Ceruloplasmin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 554 of Ceruloplasmin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ceruloplasmin between cysteines 173 and 199 (154 and 180 respectively in this structure).

Details

Redox score ?
79
PDB code
5n4l
Structure name
rat ceruloplasmin trigonal form
Structure deposition date
2017-02-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
G3V7K3
Residue number A
173
Residue number B
199
Peptide name
Ceruloplasmin

Ligandability

Cysteine 173 of Ceruloplasmin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 199 of Ceruloplasmin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ceruloplasmin between cysteines 868 and 894 (849 and 875 respectively in this structure).

Details

Redox score ?
78
PDB code
5n4l
Structure name
rat ceruloplasmin trigonal form
Structure deposition date
2017-02-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
G3V7K3
Residue number A
868
Residue number B
894
Peptide name
Ceruloplasmin

Ligandability

Cysteine 868 of Ceruloplasmin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 894 of Ceruloplasmin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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