ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma

Intramolecular
Cysteine 368 and cysteine 417
Cysteine 361 and cysteine 363
Cysteine 356 and cysteine 361
Cysteine 363 and cysteine 960
Cysteine 318 and cysteine 1060
A redox-regulated disulphide may form within 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma between cysteines 368 and 417.

Details

Redox score ?
60
PDB code
7t8t
Structure name
cryoem structure of plcg1
Structure deposition date
2021-12-17
Thiol separation (Å)
5
Half-sphere exposure sum ?
65
Minimum pKa ?
12
% buried
83
Peptide accession
G3V845
Residue number A
368
Residue number B
417
Peptide name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma

Ligandability

Cysteine 368 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 417 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma between cysteines 361 and 363. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
7t8t
Structure name
cryoem structure of plcg1
Structure deposition date
2021-12-17
Thiol separation (Å)
6
Half-sphere exposure sum ?
89
Minimum pKa ?
9
% buried
100
Peptide accession
G3V845
Residue number A
361
Residue number B
363
Peptide name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma

Ligandability

Cysteine 361 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 363 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma between cysteines 356 and 361. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
7t8t
Structure name
cryoem structure of plcg1
Structure deposition date
2021-12-17
Thiol separation (Å)
6
Half-sphere exposure sum ?
87
Minimum pKa ?
12
% buried
100
Peptide accession
G3V845
Residue number A
356
Residue number B
361
Peptide name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma

Ligandability

Cysteine 356 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 361 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma between cysteines 363 and 960. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
7t8t
Structure name
cryoem structure of plcg1
Structure deposition date
2021-12-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
77
Minimum pKa ?
9
% buried
100
Peptide accession
G3V845
Residue number A
363
Residue number B
960
Peptide name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma

Ligandability

Cysteine 363 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 960 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma between cysteines 318 and 1060. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
7t8t
Structure name
cryoem structure of plcg1
Structure deposition date
2021-12-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
55
Minimum pKa ?
9
% buried
36
Peptide accession
G3V845
Residue number A
318
Residue number B
1060
Peptide name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma

Ligandability

Cysteine 318 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1060 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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