ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11

Intramolecular
Cysteine 20 and cysteine 77
Cysteine 97 and cysteine 117
A redox-regulated disulphide may form within NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 between cysteines 20 and 77 (19 and 76 respectively in this structure).

Details

Redox score ?
69
PDB code
7ak5
Structure name
cryo-em structure of respiratory complex i in the deactive state from mus musculus at 3
Structure deposition date
2020-09-29
Thiol separation (Å)
5
Half-sphere exposure sum ?
66
Minimum pKa ?
9
% buried
14
Peptide accession
G5E814
Residue number A
20
Residue number B
77
Peptide name
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11

Ligandability

Cysteine 20 of NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 77 of NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 between cysteines 97 and 117 (94 and 114 respectively in this structure).

Details

Redox score ?
65
PDB code
6g2j
Structure name
mouse mitochondrial complex i in the active state
Structure deposition date
2018-03-23
Thiol separation (Å)
5
Half-sphere exposure sum ?
66
Minimum pKa ?
10
% buried
16
Peptide accession
G5E814
Residue number A
97
Residue number B
117
Peptide name
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11

Ligandability

Cysteine 97 of NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 117 of NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: