Glutamate receptor
Intermolecular
Cysteine 603 of Glutamate receptor 1 and cysteine 610
Cysteine 549 and cysteine 9 of Protein cornichon homolog 2
Cysteine 75 of Glutamate receptor 1 and cysteine 78
Cysteine 323 of Glutamate receptor 1 and cysteine 78
Cysteine 75 of Glutamate receptor 1 and cysteine 330
Cysteine 323 of Glutamate receptor 1 and cysteine 330
Intramolecular
Cysteine 739 and cysteine 794
Cysteine 78 and cysteine 330
7ldd A 585 D 589
A redox-regulated disulphide may form between cysteine 603 of Glutamate receptor 1 and cysteine 610 of Glutamate receptor (585 and 589 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
7ldd
Structure name
native ampa receptor
Structure deposition date
2021-01-13
Thiol separation (Å)
6
Half-sphere exposure sum ?
81
Minimum pKa ?
11
% buried
95
Peptide A name
Glutamate receptor 1
Peptide B name
Glutamate receptor
Peptide A accession
P23818
Peptide B accession
G5E8H1
Peptide A residue number
603
Peptide B residue number
610
Ligandability
Cysteine 603 of Glutamate receptor 1
Cysteine 610 of Glutamate receptor
7lde B 528 F 9
A redox-regulated disulphide may form between cysteine 549 of Glutamate receptor and cysteine 9 of Protein cornichon homolog 2 (528 and 9 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
7lde
Structure name
native ampa receptor
Structure deposition date
2021-01-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
78
Peptide A name
Glutamate receptor
Peptide B name
Protein cornichon homolog 2
Peptide A accession
G5E8H1
Peptide B accession
O35089
Peptide A residue number
549
Peptide B residue number
9
Ligandability
Cysteine 549 of Glutamate receptor
Cysteine 9 of Protein cornichon homolog 2
7lde A 57 B 57
A redox-regulated disulphide may form between cysteine 75 of Glutamate receptor 1 and cysteine 78 of Glutamate receptor (57 and 57 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
7lde
Structure name
native ampa receptor
Structure deposition date
2021-01-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glutamate receptor 1
Peptide B name
Glutamate receptor
Peptide A accession
P23818
Peptide B accession
G5E8H1
Peptide A residue number
75
Peptide B residue number
78
Ligandability
Cysteine 75 of Glutamate receptor 1
Cysteine 78 of Glutamate receptor
7ldd C 305 D 57
A redox-regulated disulphide may form between cysteine 323 of Glutamate receptor 1 and cysteine 78 of Glutamate receptor (305 and 57 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
7ldd
Structure name
native ampa receptor
Structure deposition date
2021-01-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glutamate receptor 1
Peptide B name
Glutamate receptor
Peptide A accession
P23818
Peptide B accession
G5E8H1
Peptide A residue number
323
Peptide B residue number
78
Ligandability
Cysteine 323 of Glutamate receptor 1
Cysteine 78 of Glutamate receptor
7ldd A 57 B 309
A redox-regulated disulphide may form between cysteine 75 of Glutamate receptor 1 and cysteine 330 of Glutamate receptor (57 and 309 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
7ldd
Structure name
native ampa receptor
Structure deposition date
2021-01-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glutamate receptor 1
Peptide B name
Glutamate receptor
Peptide A accession
P23818
Peptide B accession
G5E8H1
Peptide A residue number
75
Peptide B residue number
330
Ligandability
Cysteine 75 of Glutamate receptor 1
Cysteine 330 of Glutamate receptor
7lde C 305 D 309
A redox-regulated disulphide may form between cysteine 323 of Glutamate receptor 1 and cysteine 330 of Glutamate receptor (305 and 309 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
7lde
Structure name
native ampa receptor
Structure deposition date
2021-01-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glutamate receptor 1
Peptide B name
Glutamate receptor
Peptide A accession
P23818
Peptide B accession
G5E8H1
Peptide A residue number
323
Peptide B residue number
330
Ligandability
Cysteine 323 of Glutamate receptor 1
Cysteine 330 of Glutamate receptor
7ldd D 718 D 773
A redox-regulated disulphide may form within Glutamate receptor between cysteines 739 and 794 (718 and 773 respectively in this structure).
Details
Redox score ?
85
PDB code
7ldd
Structure name
native ampa receptor
Structure deposition date
2021-01-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
G5E8H1
Residue number A
739
Residue number B
794
Peptide name
Glutamate receptor
Ligandability
Cysteine 739 of Glutamate receptor
Cysteine 794 of Glutamate receptor
7ldd D 57 D 309
A redox-regulated disulphide may form within Glutamate receptor between cysteines 78 and 330 (57 and 309 respectively in this structure).
Details
Redox score ?
82
PDB code
7ldd
Structure name
native ampa receptor
Structure deposition date
2021-01-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
G5E8H1
Residue number A
78
Residue number B
330
Peptide name
Glutamate receptor
Ligandability
Cysteine 78 of Glutamate receptor
Cysteine 330 of Glutamate receptor
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