ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Structural maintenance of chromosomes protein

Intramolecular
Cysteine 501 and cysteine 591
A redox-regulated disulphide may form within Structural maintenance of chromosomes protein between cysteines 501 and 591 (523 and 613 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
6wg6
Structure name
crystal structure of human smc1-smc3 hinge domain heterodimer in north-open conformation
Structure deposition date
2020-04-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
67
Minimum pKa ?
12
% buried
82
Peptide accession
G8JLG1
Residue number A
501
Residue number B
591
Peptide name
Structural maintenance of chromosomes protein

Ligandability

Cysteine 501 of Structural maintenance of chromosomes protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 591 of Structural maintenance of chromosomes protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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