ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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YWHAE/FAM22B fusion protein

Intramolecular
Cysteine 107 and cysteine 108
A redox-regulated disulphide may form within YWHAE/FAM22B fusion protein between cysteines 107 and 108 (97 and 98 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
7v9b
Structure name
crystal structure of 14-3-3 epsilon with foxo3a peptide
Structure deposition date
2021-08-24
Thiol separation (Å)
7
Half-sphere exposure sum ?
57
Minimum pKa ?
10
% buried
62
Peptide accession
G9K389
Residue number A
107
Residue number B
108
Peptide name
YWHAE/FAM22B fusion protein

Ligandability

Cysteine 107 of YWHAE/FAM22B fusion protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 108 of YWHAE/FAM22B fusion protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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