ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Importin subunit alpha

Intermolecular
Cysteine 419 and cysteine 419
A redox-regulated disulphide may form between two units of Importin subunit alpha at cysteines 419 and 419. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
7s1e
Structure name
crystal structure of cavia porecellus (guinea pig) importin-alpha 1 in cargo-free state
Structure deposition date
2021-09-02
Thiol separation (Å)
8
Half-sphere exposure sum ?
67
Minimum pKa ?
12
% buried
94
Peptide A name
Importin subunit alpha
Peptide B name
Importin subunit alpha
Peptide A accession
H0VVB1
Peptide B accession
H0VVB1
Peptide A residue number
419
Peptide B residue number
419

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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