ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Fc gamma receptor IIIa

Intramolecular
Cysteine 46 and cysteine 88
Cysteine 127 and cysteine 171
A redox-regulated disulphide may form within Fc gamma receptor IIIa between cysteines 46 and 88 (29 and 71 respectively in this structure).

Details

Redox score ?
85
PDB code
5vu0
Structure name
crystal structure of the complex between afucosylated/galactosylated human igg1 fc and fc gamma receptor iiia (cd16a) with man5 n-glycans
Structure deposition date
2017-05-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
H0Y755
Residue number A
46
Residue number B
88
Peptide name
Fc gamma receptor IIIa

Ligandability

Cysteine 46 of Fc gamma receptor IIIa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 88 of Fc gamma receptor IIIa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Fc gamma receptor IIIa between cysteines 127 and 171 (110 and 154 respectively in this structure).

Details

Redox score ?
80
PDB code
5vu0
Structure name
crystal structure of the complex between afucosylated/galactosylated human igg1 fc and fc gamma receptor iiia (cd16a) with man5 n-glycans
Structure deposition date
2017-05-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
90
Minimum pKa ?
nan
% buried
nan
Peptide accession
H0Y755
Residue number A
127
Residue number B
171
Peptide name
Fc gamma receptor IIIa

Ligandability

Cysteine 127 of Fc gamma receptor IIIa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 171 of Fc gamma receptor IIIa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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